微生物操控者:核梭杆菌调节结直肠癌的肿瘤免疫微环境。

IF 5.5 2区 医学 Q2 MICROBIOLOGY
Journal of Oral Microbiology Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI:10.1080/20002297.2025.2544169
Qian Li, Wanyi Luo, Li Xiao, Xin Xu, Xian Peng, Lei Cheng, Xuedong Zhou, Xin Zheng
{"title":"微生物操控者:核梭杆菌调节结直肠癌的肿瘤免疫微环境。","authors":"Qian Li, Wanyi Luo, Li Xiao, Xin Xu, Xian Peng, Lei Cheng, Xuedong Zhou, Xin Zheng","doi":"10.1080/20002297.2025.2544169","DOIUrl":null,"url":null,"abstract":"<p><p><i>Fusobacterium nucleatum</i>, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how <i>F. nucleatum</i> encourages CRC tumorigenesis and progression has been well-investigated. Recently, mechanisms by which <i>F. nucleatum</i> regulates the tumor immune microenvironment (TiME) and subsequently alters CRC oncogenesis and advancement have drawn more and more attention. The TiME consists of immune cells and non-cellular components like cytokines in the tumor microenvironment. By contacting immune cells in the TiME, <i>F. nucleatum</i> fosters an immunosuppressive TiME, diminishes anti-tumor immunity and promotes CRC development. This also allows <i>F. nucleatum</i> to interfere with immunotherapy process and efficacy. In this review, we present a summary of how <i>F. nucleatum</i> interacts with immune cells within the TiME, thereby promoting CRC progression and influencing CRC immunotherapy effectiveness. This review also integrates insights from molecular pathological epidemiology (MPE) to contextualize host-microbe-environment interactions in CRC. We identify gaps in current knowledge and outline possible future research paths. These findings may offer valuable insights for future mechanistic research and the development of novel therapeutic strategies.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"17 1","pages":"2544169"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326384/pdf/","citationCount":"0","resultStr":"{\"title\":\"Microbial manipulators: <i>Fusobacterium nucleatum</i> modulates the tumor immune microenvironment in colorectal cancer.\",\"authors\":\"Qian Li, Wanyi Luo, Li Xiao, Xin Xu, Xian Peng, Lei Cheng, Xuedong Zhou, Xin Zheng\",\"doi\":\"10.1080/20002297.2025.2544169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Fusobacterium nucleatum</i>, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how <i>F. nucleatum</i> encourages CRC tumorigenesis and progression has been well-investigated. Recently, mechanisms by which <i>F. nucleatum</i> regulates the tumor immune microenvironment (TiME) and subsequently alters CRC oncogenesis and advancement have drawn more and more attention. The TiME consists of immune cells and non-cellular components like cytokines in the tumor microenvironment. By contacting immune cells in the TiME, <i>F. nucleatum</i> fosters an immunosuppressive TiME, diminishes anti-tumor immunity and promotes CRC development. This also allows <i>F. nucleatum</i> to interfere with immunotherapy process and efficacy. In this review, we present a summary of how <i>F. nucleatum</i> interacts with immune cells within the TiME, thereby promoting CRC progression and influencing CRC immunotherapy effectiveness. This review also integrates insights from molecular pathological epidemiology (MPE) to contextualize host-microbe-environment interactions in CRC. We identify gaps in current knowledge and outline possible future research paths. These findings may offer valuable insights for future mechanistic research and the development of novel therapeutic strategies.</p>\",\"PeriodicalId\":16598,\"journal\":{\"name\":\"Journal of Oral Microbiology\",\"volume\":\"17 1\",\"pages\":\"2544169\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326384/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/20002297.2025.2544169\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20002297.2025.2544169","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

核梭杆菌是一种通常在口腔中检测到的微生物,被认为是与牙周炎和一系列人类疾病(包括结直肠癌)有关的病原体。核仁梭菌促进结直肠癌肿瘤发生和进展的动力学已经得到了很好的研究。近年来,核梭菌调节肿瘤免疫微环境(TiME)进而改变结直肠癌发生和进展的机制越来越受到人们的关注。TiME由肿瘤微环境中的免疫细胞和细胞因子等非细胞成分组成。F. nucleatum通过接触TiME中的免疫细胞,培养免疫抑制TiME,降低抗肿瘤免疫,促进结直肠癌的发展。这也允许具核梭菌干扰免疫治疗过程和效果。在这篇综述中,我们总结了核梭菌如何在时间内与免疫细胞相互作用,从而促进结直肠癌的进展并影响结直肠癌的免疫治疗效果。本综述还整合了分子病理流行病学(MPE)的见解,以了解CRC中宿主-微生物-环境相互作用的背景。我们确定当前知识的差距,并概述未来可能的研究路径。这些发现可能为未来的机制研究和新治疗策略的发展提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Microbial manipulators: <i>Fusobacterium nucleatum</i> modulates the tumor immune microenvironment in colorectal cancer.

Microbial manipulators: <i>Fusobacterium nucleatum</i> modulates the tumor immune microenvironment in colorectal cancer.

Microbial manipulators: <i>Fusobacterium nucleatum</i> modulates the tumor immune microenvironment in colorectal cancer.

Microbial manipulators: Fusobacterium nucleatum modulates the tumor immune microenvironment in colorectal cancer.

Fusobacterium nucleatum, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how F. nucleatum encourages CRC tumorigenesis and progression has been well-investigated. Recently, mechanisms by which F. nucleatum regulates the tumor immune microenvironment (TiME) and subsequently alters CRC oncogenesis and advancement have drawn more and more attention. The TiME consists of immune cells and non-cellular components like cytokines in the tumor microenvironment. By contacting immune cells in the TiME, F. nucleatum fosters an immunosuppressive TiME, diminishes anti-tumor immunity and promotes CRC development. This also allows F. nucleatum to interfere with immunotherapy process and efficacy. In this review, we present a summary of how F. nucleatum interacts with immune cells within the TiME, thereby promoting CRC progression and influencing CRC immunotherapy effectiveness. This review also integrates insights from molecular pathological epidemiology (MPE) to contextualize host-microbe-environment interactions in CRC. We identify gaps in current knowledge and outline possible future research paths. These findings may offer valuable insights for future mechanistic research and the development of novel therapeutic strategies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.00
自引率
4.40%
发文量
52
审稿时长
12 weeks
期刊介绍: As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies. Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics. Article types: original articles, notes, review articles, mini-reviews and commentaries
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信