迷走神经刺激以层特异性方式调节大鼠听觉皮层持续活动的信息表征。

IF 3 3区 医学 Q2 NEUROSCIENCES
Frontiers in Neural Circuits Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI:10.3389/fncir.2025.1569158
Tomoyo Isoguchi Shiramatsu, Kenji Ibayashi, Kensuke Kawai, Hirokazu Takahashi
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引用次数: 0

摘要

了解迷走神经刺激(VNS)如何调节皮质信息处理对于开发受生物系统启发的可持续、自适应人工智能至关重要。这项研究首次证明了VNS在大鼠听觉皮层内以一种层和频带特异性的方式改变了听觉信息的表征。利用微电极阵列,我们精心绘制了大鼠听觉皮层2/3层、4层和5/6层持续活动的带特异性功率和锁相值。利用稀疏逻辑回归对测试频率进行解码,并比较了应用VNS前后的解码精度。结果表明,VNS抑制了深层(5/6层)的高伽马波段表征,增强了深层(2/3层和4层)的θ波段表征,略微改善了表层(2/3层和4层)的高伽马波段表征,显示了VNS的层特异性和频带特异性效应。这些发现表明,VNS调节听觉皮层前馈和反馈通路之间的平衡,为神经调节机制及其在脑启发计算和治疗干预中的潜在应用提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex.

Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex.

Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex.

Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex.

Understanding how vagus nerve stimulation (VNS) modulates cortical information processing is essential to developing sustainable, adaptive artificial intelligence inspired by biological systems. This study presents the first evidence that VNS alters the representation of auditory information in a manner that is both layer- and frequency band-specific within the rat auditory cortex. Using a microelectrode array, we meticulously mapped the band-specific power and phase-locking value of sustained activities in layers 2/3, 4, and 5/6, of the rat auditory cortex. We used sparse logistic regression to decode the test frequency from these neural characteristics and compared the decoding accuracy before and after applying VNS. Our results showed that VNS impairs high-gamma band representation in deeper layers (layers 5/6), enhances theta band representation in those layers, and slightly improves high-gamma representation in superficial layers (layers 2/3 and 4), demonstrating the layer-specific and frequency band-specific effect of VNS. These findings suggest that VNS modulates the balance between feed-forward and feed-back pathways in the auditory cortex, providing novel insights into the mechanisms of neuromodulation and its potential applications in brain-inspired computing and therapeutic interventions.

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来源期刊
CiteScore
6.00
自引率
5.70%
发文量
135
审稿时长
4-8 weeks
期刊介绍: Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.
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