Christos K Papagiannopoulos, Georgios Markozannes, Christos V Chalitsios, Sofia Christakoudi, Marc J Gunter, Laure Dossus, Richard M Martin, Ioanna Tzoulaki, Christopher Papandreou, Konstantinos K Tsilidis
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MSs performance was validated in an independent cohort.</p><p><strong>Findings: </strong>In females, MSs mainly consisted of lipoprotein particle concentrations, apolipoproteins, fatty acids and inflammation-linked glycoprotein acetyls, whereas in males lipoproteins rich in cholesteryl esters and aromatic/branched-chain amino acids predominated. The highest percentages of common metabolites were observed between non-allometric adiposity indices (median: 42.4%; range: 9%-56%). MSs were independently associated with over 25 biomarkers with differences observed by sex and adiposity index, and these associations were stronger compared to the respective phenotypic associations.</p><p><strong>Interpretation: </strong>MS<sub>ABSI</sub> was found to be more atherogenic, whereas MS<sub>HI</sub> was more favourable for health. This study highlights i) that different regions of adipose tissue undergo distinct metabolic processes overall and by sex, each having unique impact on health, and ii) the importance of considering metabolic factors beyond simple adiposity indices in assessing health risk.</p><p><strong>Funding: </strong>This work was supported by Cancer Research UK (grant number C18281/A29019).</p>","PeriodicalId":11494,"journal":{"name":"EBioMedicine","volume":"119 ","pages":"105868"},"PeriodicalIF":10.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sex-stratified metabolic signatures of adiposity indices and their associations with clinical biomarkers in the UK Biobank.\",\"authors\":\"Christos K Papagiannopoulos, Georgios Markozannes, Christos V Chalitsios, Sofia Christakoudi, Marc J Gunter, Laure Dossus, Richard M Martin, Ioanna Tzoulaki, Christopher Papandreou, Konstantinos K Tsilidis\",\"doi\":\"10.1016/j.ebiom.2025.105868\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Excessive adiposity increases disease risk, however, the metabolic processes underlying these associations remain incompletely understood.</p><p><strong>Methods: </strong>We compared metabolic signatures (MSs) of adiposity indices (non-allometric: body fat %, waist circumference, hip circumference, waist-to-hip ratio, body mass index; allometric: a body shape index [ABSI], hip index [HI], waist-to-HI ratio) by sex and examined their cross-sectional associations with 29 clinical biomarkers in 151,526 UK Biobank participants. 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Sex-stratified metabolic signatures of adiposity indices and their associations with clinical biomarkers in the UK Biobank.
Background: Excessive adiposity increases disease risk, however, the metabolic processes underlying these associations remain incompletely understood.
Methods: We compared metabolic signatures (MSs) of adiposity indices (non-allometric: body fat %, waist circumference, hip circumference, waist-to-hip ratio, body mass index; allometric: a body shape index [ABSI], hip index [HI], waist-to-HI ratio) by sex and examined their cross-sectional associations with 29 clinical biomarkers in 151,526 UK Biobank participants. MSs performance was validated in an independent cohort.
Findings: In females, MSs mainly consisted of lipoprotein particle concentrations, apolipoproteins, fatty acids and inflammation-linked glycoprotein acetyls, whereas in males lipoproteins rich in cholesteryl esters and aromatic/branched-chain amino acids predominated. The highest percentages of common metabolites were observed between non-allometric adiposity indices (median: 42.4%; range: 9%-56%). MSs were independently associated with over 25 biomarkers with differences observed by sex and adiposity index, and these associations were stronger compared to the respective phenotypic associations.
Interpretation: MSABSI was found to be more atherogenic, whereas MSHI was more favourable for health. This study highlights i) that different regions of adipose tissue undergo distinct metabolic processes overall and by sex, each having unique impact on health, and ii) the importance of considering metabolic factors beyond simple adiposity indices in assessing health risk.
Funding: This work was supported by Cancer Research UK (grant number C18281/A29019).
EBioMedicineBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍：
eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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