{"title":"基于脂质代谢重编程的中药防治肝癌侵袭转移机制研究进展","authors":"Mengke Wang, Hanning Lyu, Yuxin Liu, Yang Sun","doi":"10.2174/0115680266366687250730060318","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatocellular Carcinoma (HCC) represents a common malignant tumor worldwide, having a profound effect on human health. The processes of invasion and spreading to distant sites are critical malignant biological behaviors exhibited by tumors. The metabolic environment is intricately linked to the initiation, invasion, and subsequent dissemination of tumor cells, with a particular emphasis on lipid metabolism. Lipid metabolism plays a vital role in mediating membrane structure, providing energy, and facilitating signal transduction. It not only delivers energy sources for tumor cells but also establishes conditions conducive to the initiation, progression, and spread of HCC. To meet their energy demands, tumor cells undergo a process of lipid metabolic reprogramming, characterized here as abnormal lipid metabolism. Therefore, a comprehensive investigation into the mechanisms underpinning lipid metabolic reprogramming and its influence on HCC growth and dissemination is crucial for the prevention, early detection, and identification of novel therapeutic targets for HCC. This article initially delineates the metabolic pathways of fatty acids within cells during the development and progression of HCC. It then reviews recent advancements in understanding abnormal lipid metabolism, focusing on the associated genes, enzymes, proteins, and metabolic products that promote HCC progression and spread. Furthermore, a brief overview of the Tumor Immune Microenvironment (TIME) in HCC is provided, highlighting the interactions between Tumor-Associated Macrophages (TAMs) and HCC lipid metabolic reprogramming, as well as their effects on HCC growth and dissemination. Lastly, it examines the treatments targeting abnormal lipid metabolism in HCC utilizing Traditional Chinese Medicine (TCM) and natural products, offering new perspectives for targeting HCC lipid metabolic reprogramming to inhibit spread and invasion.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming.\",\"authors\":\"Mengke Wang, Hanning Lyu, Yuxin Liu, Yang Sun\",\"doi\":\"10.2174/0115680266366687250730060318\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hepatocellular Carcinoma (HCC) represents a common malignant tumor worldwide, having a profound effect on human health. The processes of invasion and spreading to distant sites are critical malignant biological behaviors exhibited by tumors. The metabolic environment is intricately linked to the initiation, invasion, and subsequent dissemination of tumor cells, with a particular emphasis on lipid metabolism. Lipid metabolism plays a vital role in mediating membrane structure, providing energy, and facilitating signal transduction. It not only delivers energy sources for tumor cells but also establishes conditions conducive to the initiation, progression, and spread of HCC. To meet their energy demands, tumor cells undergo a process of lipid metabolic reprogramming, characterized here as abnormal lipid metabolism. Therefore, a comprehensive investigation into the mechanisms underpinning lipid metabolic reprogramming and its influence on HCC growth and dissemination is crucial for the prevention, early detection, and identification of novel therapeutic targets for HCC. This article initially delineates the metabolic pathways of fatty acids within cells during the development and progression of HCC. It then reviews recent advancements in understanding abnormal lipid metabolism, focusing on the associated genes, enzymes, proteins, and metabolic products that promote HCC progression and spread. Furthermore, a brief overview of the Tumor Immune Microenvironment (TIME) in HCC is provided, highlighting the interactions between Tumor-Associated Macrophages (TAMs) and HCC lipid metabolic reprogramming, as well as their effects on HCC growth and dissemination. Lastly, it examines the treatments targeting abnormal lipid metabolism in HCC utilizing Traditional Chinese Medicine (TCM) and natural products, offering new perspectives for targeting HCC lipid metabolic reprogramming to inhibit spread and invasion.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266366687250730060318\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266366687250730060318","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming.
Hepatocellular Carcinoma (HCC) represents a common malignant tumor worldwide, having a profound effect on human health. The processes of invasion and spreading to distant sites are critical malignant biological behaviors exhibited by tumors. The metabolic environment is intricately linked to the initiation, invasion, and subsequent dissemination of tumor cells, with a particular emphasis on lipid metabolism. Lipid metabolism plays a vital role in mediating membrane structure, providing energy, and facilitating signal transduction. It not only delivers energy sources for tumor cells but also establishes conditions conducive to the initiation, progression, and spread of HCC. To meet their energy demands, tumor cells undergo a process of lipid metabolic reprogramming, characterized here as abnormal lipid metabolism. Therefore, a comprehensive investigation into the mechanisms underpinning lipid metabolic reprogramming and its influence on HCC growth and dissemination is crucial for the prevention, early detection, and identification of novel therapeutic targets for HCC. This article initially delineates the metabolic pathways of fatty acids within cells during the development and progression of HCC. It then reviews recent advancements in understanding abnormal lipid metabolism, focusing on the associated genes, enzymes, proteins, and metabolic products that promote HCC progression and spread. Furthermore, a brief overview of the Tumor Immune Microenvironment (TIME) in HCC is provided, highlighting the interactions between Tumor-Associated Macrophages (TAMs) and HCC lipid metabolic reprogramming, as well as their effects on HCC growth and dissemination. Lastly, it examines the treatments targeting abnormal lipid metabolism in HCC utilizing Traditional Chinese Medicine (TCM) and natural products, offering new perspectives for targeting HCC lipid metabolic reprogramming to inhibit spread and invasion.
期刊介绍:
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.