局部麻醉与癌症生物学的交叉:现在该怎么办?我们要去哪里?

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Eduardo Nunez-Rodriguez, Hao Zhang, Dhananjay Sah, Juan P Cata
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引用次数: 0

摘要

局麻药(LAs),通常用于区域和全身麻醉,近年来因其在癌症治疗手术中的潜在作用而受到关注,因为它们可以减少癌症的复发和进展。实验室和动物模型的研究表明,LAs可以通过限制癌细胞的侵袭和迁移,抑制肿瘤生长和细胞增殖,引发细胞凋亡,减少转移。此外,LAs通过调节炎症、增强免疫反应、阻断血管生成、干扰肿瘤神经支配等方式影响肿瘤微环境。这些作用背后的机制涉及电压门控钠通道依赖性和独立通路,如AKT/mTOR、RAS/ERK和SRC/STAT3,以及调节microrna、环状rna和凋亡相关蛋白等。此外,LAs可能会提高化疗的疗效,并抵消化疗耐药。这篇综述的目的是全面总结目前关于LAs影响肿瘤发生、改变转移过程、调节免疫反应和影响肿瘤微环境内血管生成的各种机制的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Local anesthetics (LAs), commonly  used for   regional and  general anesthesia, have gained attention in recent  years for their potential role during cancer curative surgery, as they may reduce cancer recurrence and progression. Studies in both laboratory and animal models have shown that LAs can inhibit tumor growth and cell proliferation, trigger apoptosis, and reduce metastasis by limiting cancer cell invasion and migration. In addition, LAs impact the tumor microenvironment by modulating inflammation, enhancing the immune response, blocking angiogenesis, and interfering with tumor innervation. The mechanisms behind these effects involve both voltage-gated sodium channel-dependent and independent pathways, such as AKT/mTOR, RAS/ERK, and SRC/STAT3, as well as regulating microRNAs, circular RNAs, and apoptosis-related proteins, among others. Furthermore, LAs may enhance the efficacy of chemotherapy and counteract chemoresistance. The aim of this review is to provide a comprehensive summary of the current literature on the various mechanisms through which LAs influence tumorigenesis, alter metastasis processes, modulate immune responses, and affect angiogenesis within the tumor microenvironment.

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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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