{"title":"为自噬搭建桥梁","authors":"Anne Schreiber","doi":"10.1038/s41594-025-01628-z","DOIUrl":null,"url":null,"abstract":"A study reveals how the TRAPPIII complex and Atg2 establish membrane contact sites between the growing autophagosomal membrane and the endoplasmic reticulum, coordinating Rab GTPase signaling and lipid transfer to drive autophagosome formation.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"288 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Building bridges for autophagy\",\"authors\":\"Anne Schreiber\",\"doi\":\"10.1038/s41594-025-01628-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A study reveals how the TRAPPIII complex and Atg2 establish membrane contact sites between the growing autophagosomal membrane and the endoplasmic reticulum, coordinating Rab GTPase signaling and lipid transfer to drive autophagosome formation.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"288 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01628-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01628-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A study reveals how the TRAPPIII complex and Atg2 establish membrane contact sites between the growing autophagosomal membrane and the endoplasmic reticulum, coordinating Rab GTPase signaling and lipid transfer to drive autophagosome formation.