Matthew V Elliott, Ming Hsu, Lucina Q Uddin, Kiana Modavi, Sheri L Johnson
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Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity.
Emotion-related impulsivity (ERI) shows robust longitudinal associations with psychiatric disorders, aggression, and suicidality, yet a parsimonious account of its neurocognitive correlates has not been offered. We connect ERI with the Glutamate Amplifies Noradrenergic Effects (GANE) model, a framework describing how norepinephrine tunes "hotspots" of brain activation during heightened physiological arousal. First, we systematically reviewed studies of ERI and task-based functional MRI. Meta-analysis of significant effects yielded one cluster in right inferior frontal gyrus. 26 of 30 significant effects systematically co-localized in neuroanatomical "hotspots" in each corresponding task, in line with GANE. Second, adults recruited for a range of psychopathology (n = 120) completed a reward/punishment Go No-Go task while undergoing functional MRI. ERI correlated with stronger nucleus accumbens activation for a model sensitive to heightened trial reward and in anterior cingulate for models sensitive to heightened trial arousal. Findings provide empirical support for the relevance of GANE "hotspot" mechanisms to ERI.
期刊介绍：
The Association for Psychological Science’s journal, Clinical Psychological Science, emerges from this confluence to provide readers with the best, most innovative research in clinical psychological science, giving researchers of all stripes a home for their work and a place in which to communicate with a broad audience of both clinical and other scientists.
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