前列腺的腺体和细胞水平异质性:相关疾病的叙述性回顾。

IF 1.3 4区 医学 Q4 UROLOGY & NEPHROLOGY
Current Urology Pub Date : 2025-07-01 Epub Date: 2025-01-17 DOI:10.1097/CU9.0000000000000269
Gang Wang, Cai Lv, Zhenxiang Liu, Mengxing Huang, Yu Zhang, Jing Chen, Jinyue Hu, Yiling Jin, Zhiming Bai
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引用次数: 0

摘要

由于前列腺的解剖特点,良性前列腺增生(BPH)多发生在过渡区,而前列腺癌(PCa)多发生在外周区。这种分布特征表明前列腺具有细胞类型和分布的异质性。然而,目前的研究还不能准确地回答这些问题。随着研究的深入,许多新发现的细胞类型对BPH和PCa的治疗意义引起了广泛关注。前列腺异质性与腺体发育、形成和疾病的区域分布密切相关。前列腺异质性可以在腺体和细胞水平上观察到,并决定疾病的分布、表现和特征,包括前列腺增生和前列腺癌微环境的变化。细胞群的相互作用促进疾病的发生和发展;单细胞测序技术可能有助于阐明不同前列腺区域的特定细胞类型和基因表达模式。俱乐部/丘细胞的干细胞特征和免疫细胞诱导的炎症环境为BPH和PCa的致病机制提供了不同的解释,分子组学研究可以帮助确定治疗开发的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gland- and cell-level heterogeneity in the prostate: A narrative review of related diseases.

Because of the anatomical characteristics of the prostate, benign prostatic hyperplasia (BPH) often occurs in the transition zone, whereas prostate cancer (PCa) tends to occur in the peripheral zone. This distribution characteristic indicates that the prostate gland has cell type and distribution heterogeneity. However, the current research cannot answer these questions precisely. As research has progressed, the significance of many newly discovered cell types for the treatment of BPH and PCa has sparked widespread concern. Prostate heterogeneity is closely associated with gland development and formation and the regional distribution of the disease. Prostate heterogeneity can be observed at the gland and cell levels and determines disease distribution, presentation, and characteristics, including changes in the microenvironments of BPH and PCa. Cell population interactions promote disease onset and development; single-cell sequencing techniques may help elucidate specific cell types and gene expression patterns in different prostate zones. The stem cell characteristics of club/hillock cells and the inflammatory environment induced by immune cells offer alternative interpretations of the pathogenic mechanisms of BPH and PCa, and molecular omics studies can help identify novel avenues for treatment development.

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来源期刊
Current Urology
Current Urology Medicine-Urology
CiteScore
2.30
自引率
0.00%
发文量
96
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