{"title":"研究运动对氯氮平治疗的精神分裂症患者临床症状、认知表现和生活质量的影响。","authors":"İsmail Koç, Ebru Akbuğa Koç","doi":"10.1080/13651501.2025.2542785","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This prospective study aims to investigate the effects of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine.</p><p><strong>Methods: </strong>Fifty-six (<i>n</i> = 56) participants were completed as the physical exercise group (PEG) (<i>n</i> = 28) and control group (CG) (<i>n</i> = 28). The PEG participated in an exercise program lasting 30 min, three times a week, for 12 weeks, in addition to a routine ergotherapy programme. The CG did not receive any treatment other than ergotherapy programme. Sociodemographic characteristics, Positive and Negative Syndrome Scale (PANNS), Brief Psychiatric Rating Scale (BPRS), Montreal Cognitive Assessment (MOCA), and The World Health Organisation Quality of Life (WHQOL-BREF) evaluated at baseline and after 12 weeks for both groups.</p><p><strong>Results: </strong>After intervention, a statistically significant increase was observed in the MOCA and the psychological health sub-parameter of WHQOL-BREF in the PEG (<i>p</i> ≤ 0.05). According to the intergroup change analysis, the changes in the cognitive performance and psychological health sub-parameter of quality-of-life scores were significantly higher in the PEG than in the CG (<i>p</i> ≤ 0.05).</p><p><strong>Conclusion: </strong>The demonstrated improvement in cognitive performance and psychological health in patients with schizophrenia treated with Clozapine through physical exercise strongly advocates for the inclusion of structured exercise programs in comprehensive treatment plans.</p>","PeriodicalId":14351,"journal":{"name":"International Journal of Psychiatry in Clinical Practice","volume":" ","pages":"1-10"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the effect of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine.\",\"authors\":\"İsmail Koç, Ebru Akbuğa Koç\",\"doi\":\"10.1080/13651501.2025.2542785\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This prospective study aims to investigate the effects of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine.</p><p><strong>Methods: </strong>Fifty-six (<i>n</i> = 56) participants were completed as the physical exercise group (PEG) (<i>n</i> = 28) and control group (CG) (<i>n</i> = 28). The PEG participated in an exercise program lasting 30 min, three times a week, for 12 weeks, in addition to a routine ergotherapy programme. The CG did not receive any treatment other than ergotherapy programme. Sociodemographic characteristics, Positive and Negative Syndrome Scale (PANNS), Brief Psychiatric Rating Scale (BPRS), Montreal Cognitive Assessment (MOCA), and The World Health Organisation Quality of Life (WHQOL-BREF) evaluated at baseline and after 12 weeks for both groups.</p><p><strong>Results: </strong>After intervention, a statistically significant increase was observed in the MOCA and the psychological health sub-parameter of WHQOL-BREF in the PEG (<i>p</i> ≤ 0.05). According to the intergroup change analysis, the changes in the cognitive performance and psychological health sub-parameter of quality-of-life scores were significantly higher in the PEG than in the CG (<i>p</i> ≤ 0.05).</p><p><strong>Conclusion: </strong>The demonstrated improvement in cognitive performance and psychological health in patients with schizophrenia treated with Clozapine through physical exercise strongly advocates for the inclusion of structured exercise programs in comprehensive treatment plans.</p>\",\"PeriodicalId\":14351,\"journal\":{\"name\":\"International Journal of Psychiatry in Clinical Practice\",\"volume\":\" \",\"pages\":\"1-10\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Psychiatry in Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/13651501.2025.2542785\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychiatry in Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13651501.2025.2542785","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Investigating the effect of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine.
Background: This prospective study aims to investigate the effects of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with clozapine.
Methods: Fifty-six (n = 56) participants were completed as the physical exercise group (PEG) (n = 28) and control group (CG) (n = 28). The PEG participated in an exercise program lasting 30 min, three times a week, for 12 weeks, in addition to a routine ergotherapy programme. The CG did not receive any treatment other than ergotherapy programme. Sociodemographic characteristics, Positive and Negative Syndrome Scale (PANNS), Brief Psychiatric Rating Scale (BPRS), Montreal Cognitive Assessment (MOCA), and The World Health Organisation Quality of Life (WHQOL-BREF) evaluated at baseline and after 12 weeks for both groups.
Results: After intervention, a statistically significant increase was observed in the MOCA and the psychological health sub-parameter of WHQOL-BREF in the PEG (p ≤ 0.05). According to the intergroup change analysis, the changes in the cognitive performance and psychological health sub-parameter of quality-of-life scores were significantly higher in the PEG than in the CG (p ≤ 0.05).
Conclusion: The demonstrated improvement in cognitive performance and psychological health in patients with schizophrenia treated with Clozapine through physical exercise strongly advocates for the inclusion of structured exercise programs in comprehensive treatment plans.
期刊介绍：
International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry.
The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice.
Focus on the practical aspects of managing and treating patients.
Essential reading for the busy psychiatrist, trainee and interested physician.
Includes original research papers, comprehensive review articles and short communications.
Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.
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