快速止血,抗菌多功能明胶基水凝胶敷料加载双功能Cu/ZIF-8加速伤口愈合。

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS
Zhichao Zhang, Xijing Zhuang, Xufeng Dong, Jingyuan Zhao, Hao Zhang, Hong Zheng* and Chang Xu*, 
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引用次数: 0

摘要

受伤后,人体湿润的伤口环境极易受到微生物定植和随后的感染,可能引发长期的炎症反应。现有的敷料往往功能单一,难以同时处理伤口出血和细菌生长。开发更有效的伤口敷料是当代伤口护理的关键优先事项。在这项研究中,我们开发了一种水凝胶伤口敷料,包括两种成分:(1)姜黄素(Cur)负载的双金属有机框架(Cu/ZIF-8)的抗菌颗粒,以及(2)由甲基丙烯酰化明胶(GelMA)与甲基丙烯酰化透明质酸(HAMA)交联形成的载体水凝胶。实验结果表明,Cu/ZIF-8@Cur的负载率为45.6%。此外,该材料还表现出ph响应行为,良好的生物相容性(>80%的细胞存活率),低溶血活性(大肠杆菌和金黄色葡萄球菌)。在中性条件下稳定,在细菌感染下(酸性环境下)释放杀菌颗粒,达到杀菌效果。本研究解决了明胶基敷料的局限性,如止血能力不足和抗菌性能弱,并展示了临床转化的良好潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fast Hemostatic, Antimicrobial Multifunctional Gelatin-Based Hydrogel Dressing Loading Bifunctional Cu/ZIF-8 for Accelerated Wound Healing

Fast Hemostatic, Antimicrobial Multifunctional Gelatin-Based Hydrogel Dressing Loading Bifunctional Cu/ZIF-8 for Accelerated Wound Healing

The moist wound environment of the human body immediately following injury is highly susceptible to microbial colonization and subsequent infection, potentially triggering a prolonged inflammatory response. Existing dressings tend to be more monofunctional, making it difficult to cope with wound bleeding and bacterial growth at the same time. The development of more effective wound dressings is a critical priority in contemporary wound care. In this study, we developed a hydrogel wound dressing comprising two components: (1) antimicrobial particles of curcumin (Cur)-loaded bimetallic organic framework (Cu/ZIF-8), and (2) a carrier hydrogel formed by methacryloylated gelatin (GelMA) cross-linked with methacryloylated hyaluronic acid (HAMA). The experimental results confirmed the successful loading of curcumin with 45.6% for Cu/ZIF-8@Cur. In addition, the material exhibits pH-responsive behavior, excellent biocompatibility (>80% cell survival), low hemolytic activity (<5%), and potent antimicrobial activity (≥99%) against E. coli and S. aureus. It is stable under neutral conditions and releases bactericidal particles under bacterial infection (in an acidic environment) to achieve sterilization. This study addresses the limitations of gelatin-based dressings, such as inadequate hemostatic capacity and weak antimicrobial performance, and it demonstrates promising potential for clinical translation.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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