PFOA诱导相分离磷脂囊泡的裂变

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-08-06 DOI:10.1039/d5cc03353e

Seungsu Han, Emad Pirhadi, Xin Yong, Sangwoo Shin

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引用次数: 0

摘要

全氟烷基和多氟烷基物质（PFAS）以其强大的表面活性而闻名，这使得它们很容易破坏细胞膜。在这里，我们研究了全氟辛酸（PFOA）是环境中最广泛的PFAS物种之一，如何与相分离的三元囊泡作为细胞膜的模型系统相互作用。实验表明，PFOA诱导囊泡沿相边界发生快速裂变。全原子分子动力学模拟表明，裂变过程背后的机制归因于与PFOA相互作用后囊泡自发曲率的急剧变化。我们的研究结果揭示了PFAS对相分离囊泡动力学的重要性，这意味着PFAS暴露对细胞膜具有潜在的破坏性影响。

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PFOA induces fission of phase-separated phospholipid vesicles

Per- and polyfluoroalkyl substances (PFAS) are known for their strong surface activity, making them easy to disrupt cellular membranes. Here, we examine how perfluorooctanoic acid (PFOA), one of the most widespread PFAS species in the environment, interacts with phase-separated ternary vesicles as a model system for cellular membranes. We show experimentally that PFOA induces a rapid fission of the vesicle along the phase boundary. All-atom molecular dynamics simulations suggest that the mechanism behind the fission process is attributed to the drastic change in the spontaneous curvature of the vesicle upon interacting with PFOA. Our findings reveal the significance of PFAS on the dynamics of phase-separated vesicles, implying a potential disruptive impact of PFAS exposure on cellular membranes.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.