Abdalhakim Shubietah, Mohammad Bdair, Anwar Zahran, Mohammed AbuBaha, Maisam Tobeh, Abubakar Nazir, Mohamed S Elgendy, Ameer Awashra, Mohammed Tareq Mutar, Jehad Zeidalkilani, Hosam I Taha, Fathi Milhem, Ahmed Emara, Suleiman Khreshi, Abdallah Hussein
{"title":"EXPRESS：美国炎症性肠病相关心血管死亡率的二十年：来自国家死亡登记的时间趋势和人口统计学差异。","authors":"Abdalhakim Shubietah, Mohammad Bdair, Anwar Zahran, Mohammed AbuBaha, Maisam Tobeh, Abubakar Nazir, Mohamed S Elgendy, Ameer Awashra, Mohammed Tareq Mutar, Jehad Zeidalkilani, Hosam I Taha, Fathi Milhem, Ahmed Emara, Suleiman Khreshi, Abdallah Hussein","doi":"10.1177/10815589251366911","DOIUrl":null,"url":null,"abstract":"<p><p>While the link between inflammatory bowel disease (IBD) and cardiovascular disease (CVD) is established, long-term trends in cardiovascular mortality among IBD patients remain unclear. This nationwide study analyzed U.S. mortality data from 1999-2020 using the CDC's Wide-ranging Online Data for Epidemiologic Research. We identified deaths with CVD as the underlying cause and IBD as a contributing factor, calculating age-adjusted mortality rates (AAMRs) by demographic and geographic factors. Among 11,891 CVD deaths linked to IBD, AAMRs declined significantly from 1999 to 2015 (-2.74% annually; <i>p</i> = 0.0064), then plateaued. Post-2015 increases were noted among Black individuals (+23.03%, 2017-2020; <i>p</i> = 0.0416) and men (+27.19%, 2018-2020; <i>p</i> = 0.0100). Mortality was highest among White and non-Hispanic populations, with regional variation. Forecasting models project rising mortality through 2040, especially among men and White individuals. These trends highlight persistent disparities and the need for targeted cardiovascular risk reduction in IBD populations.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251366911"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Temporal trends and disparities in cardiovascular mortality among individuals with inflammatory bowel disease: A U.S. nationwide analysis.\",\"authors\":\"Abdalhakim Shubietah, Mohammad Bdair, Anwar Zahran, Mohammed AbuBaha, Maisam Tobeh, Abubakar Nazir, Mohamed S Elgendy, Ameer Awashra, Mohammed Tareq Mutar, Jehad Zeidalkilani, Hosam I Taha, Fathi Milhem, Ahmed Emara, Suleiman Khreshi, Abdallah Hussein\",\"doi\":\"10.1177/10815589251366911\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>While the link between inflammatory bowel disease (IBD) and cardiovascular disease (CVD) is established, long-term trends in cardiovascular mortality among IBD patients remain unclear. This nationwide study analyzed U.S. mortality data from 1999-2020 using the CDC's Wide-ranging Online Data for Epidemiologic Research. We identified deaths with CVD as the underlying cause and IBD as a contributing factor, calculating age-adjusted mortality rates (AAMRs) by demographic and geographic factors. Among 11,891 CVD deaths linked to IBD, AAMRs declined significantly from 1999 to 2015 (-2.74% annually; <i>p</i> = 0.0064), then plateaued. Post-2015 increases were noted among Black individuals (+23.03%, 2017-2020; <i>p</i> = 0.0416) and men (+27.19%, 2018-2020; <i>p</i> = 0.0100). Mortality was highest among White and non-Hispanic populations, with regional variation. Forecasting models project rising mortality through 2040, especially among men and White individuals. These trends highlight persistent disparities and the need for targeted cardiovascular risk reduction in IBD populations.</p>\",\"PeriodicalId\":520677,\"journal\":{\"name\":\"Journal of investigative medicine : the official publication of the American Federation for Clinical Research\",\"volume\":\" \",\"pages\":\"10815589251366911\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of investigative medicine : the official publication of the American Federation for Clinical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/10815589251366911\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/10815589251366911","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Temporal trends and disparities in cardiovascular mortality among individuals with inflammatory bowel disease: A U.S. nationwide analysis.
While the link between inflammatory bowel disease (IBD) and cardiovascular disease (CVD) is established, long-term trends in cardiovascular mortality among IBD patients remain unclear. This nationwide study analyzed U.S. mortality data from 1999-2020 using the CDC's Wide-ranging Online Data for Epidemiologic Research. We identified deaths with CVD as the underlying cause and IBD as a contributing factor, calculating age-adjusted mortality rates (AAMRs) by demographic and geographic factors. Among 11,891 CVD deaths linked to IBD, AAMRs declined significantly from 1999 to 2015 (-2.74% annually; p = 0.0064), then plateaued. Post-2015 increases were noted among Black individuals (+23.03%, 2017-2020; p = 0.0416) and men (+27.19%, 2018-2020; p = 0.0100). Mortality was highest among White and non-Hispanic populations, with regional variation. Forecasting models project rising mortality through 2040, especially among men and White individuals. These trends highlight persistent disparities and the need for targeted cardiovascular risk reduction in IBD populations.
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