{"title":"日本爱媛地区铁鼻蝽中甲型冠状病毒的检测。","authors":"Hirohito Ogawa, Ryusei Kuwata, Shumpei Watanabe, Atsushi Nakamoto, Shuji Yachimori, Makoto Takeishi, Ryota Niino, Haruhiko Isawa, Ken Maeda, Yasuhiro Yoshikawa","doi":"10.1016/j.meegid.2025.105809","DOIUrl":null,"url":null,"abstract":"<p><p>Bats are suspected reservoirs for several emerging viruses, including coronaviruses. Here, we report the detection of coronaviruses in the insectivorous bat, Rhinolophus ferrumequinum, in Ehime Prefecture, located in Shikoku, the smallest of the four main islands of Japan. Phylogenetic analysis of the partial sequence of the RNA-dependent RNA polymerase gene revealed that alphacoronaviruses have circulated throughout Ehime. Additionally, the near whole-genome sequence of the identified virus (EhRf2310-18) was closely related to that of BtRf-alphaCoV/HuB2013 identified in R. ferrumequinum in China (93.062 % overall nucleotide identity), indicating that bat coronaviruses circulating in Ehime belong to the Decacovirus subgenus of Alphacoronavirus. Alphacoronaviruses in R. ferrumequinum may be strongly adapted to this species, and are distributed across a wide area between Ehime and China.</p>","PeriodicalId":54986,"journal":{"name":"Infection Genetics and Evolution","volume":" ","pages":"105809"},"PeriodicalIF":2.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Detection of alphacoronaviruses in Rhinolophus ferrumequinum in Ehime, Japan.\",\"authors\":\"Hirohito Ogawa, Ryusei Kuwata, Shumpei Watanabe, Atsushi Nakamoto, Shuji Yachimori, Makoto Takeishi, Ryota Niino, Haruhiko Isawa, Ken Maeda, Yasuhiro Yoshikawa\",\"doi\":\"10.1016/j.meegid.2025.105809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bats are suspected reservoirs for several emerging viruses, including coronaviruses. Here, we report the detection of coronaviruses in the insectivorous bat, Rhinolophus ferrumequinum, in Ehime Prefecture, located in Shikoku, the smallest of the four main islands of Japan. Phylogenetic analysis of the partial sequence of the RNA-dependent RNA polymerase gene revealed that alphacoronaviruses have circulated throughout Ehime. Additionally, the near whole-genome sequence of the identified virus (EhRf2310-18) was closely related to that of BtRf-alphaCoV/HuB2013 identified in R. ferrumequinum in China (93.062 % overall nucleotide identity), indicating that bat coronaviruses circulating in Ehime belong to the Decacovirus subgenus of Alphacoronavirus. Alphacoronaviruses in R. ferrumequinum may be strongly adapted to this species, and are distributed across a wide area between Ehime and China.</p>\",\"PeriodicalId\":54986,\"journal\":{\"name\":\"Infection Genetics and Evolution\",\"volume\":\" \",\"pages\":\"105809\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection Genetics and Evolution\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.meegid.2025.105809\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Genetics and Evolution","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.meegid.2025.105809","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Detection of alphacoronaviruses in Rhinolophus ferrumequinum in Ehime, Japan.
Bats are suspected reservoirs for several emerging viruses, including coronaviruses. Here, we report the detection of coronaviruses in the insectivorous bat, Rhinolophus ferrumequinum, in Ehime Prefecture, located in Shikoku, the smallest of the four main islands of Japan. Phylogenetic analysis of the partial sequence of the RNA-dependent RNA polymerase gene revealed that alphacoronaviruses have circulated throughout Ehime. Additionally, the near whole-genome sequence of the identified virus (EhRf2310-18) was closely related to that of BtRf-alphaCoV/HuB2013 identified in R. ferrumequinum in China (93.062 % overall nucleotide identity), indicating that bat coronaviruses circulating in Ehime belong to the Decacovirus subgenus of Alphacoronavirus. Alphacoronaviruses in R. ferrumequinum may be strongly adapted to this species, and are distributed across a wide area between Ehime and China.
期刊介绍：
(aka Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases -- MEEGID)
Infectious diseases constitute one of the main challenges to medical science in the coming century. The impressive development of molecular megatechnologies and of bioinformatics have greatly increased our knowledge of the evolution, transmission and pathogenicity of infectious diseases. Research has shown that host susceptibility to many infectious diseases has a genetic basis. Furthermore, much is now known on the molecular epidemiology, evolution and virulence of pathogenic agents, as well as their resistance to drugs, vaccines, and antibiotics. Equally, research on the genetics of disease vectors has greatly improved our understanding of their systematics, has increased our capacity to identify target populations for control or intervention, and has provided detailed information on the mechanisms of insecticide resistance.
However, the genetics and evolutionary biology of hosts, pathogens and vectors have tended to develop as three separate fields of research. This artificial compartmentalisation is of concern due to our growing appreciation of the strong co-evolutionary interactions among hosts, pathogens and vectors.
Infection, Genetics and Evolution and its companion congress [MEEGID](http://www.meegidconference.com/) (for Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases) are the main forum acting for the cross-fertilization between evolutionary science and biomedical research on infectious diseases.
Infection, Genetics and Evolution is the only journal that welcomes articles dealing with the genetics and evolutionary biology of hosts, pathogens and vectors, and coevolution processes among them in relation to infection and disease manifestation. All infectious models enter the scope of the journal, including pathogens of humans, animals and plants, either parasites, fungi, bacteria, viruses or prions. The journal welcomes articles dealing with genetics, population genetics, genomics, postgenomics, gene expression, evolutionary biology, population dynamics, mathematical modeling and bioinformatics. We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .
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