精神障碍患者口腔微生物组组成的改变:一项系统综述和荟萃分析。

IF 5.5 2区 医学 Q2 MICROBIOLOGY
Journal of Oral Microbiology Pub Date : 2025-08-03 eCollection Date: 2025-01-01 DOI:10.1080/20002297.2025.2541828
Dingxin Cao, Jun Yang, Yiwen He, Xinkang Zheng, Yanan Li, Yadong Chen, Yan Tu
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引用次数: 0

摘要

新兴研究强调了精神障碍病理生理学中的肠-脑轴,但口腔微生物组对精神健康的贡献仍未得到充分探索。阐明精神和神经疾病的口腔微生物特征可能揭示新的病理生物学机制,并为精确诊断和微生物群靶向干预提供生物标志物的发现。方法:本系统综述和荟萃分析通过综合来自PubMed、Embase和Cochrane图书馆的20项病例对照研究的数据,调查了6种不同精神障碍患者口腔微生物群的变化。从组间比较中提取相对微生物丰度和β多样性指数。对α多样性进行随机效应荟萃分析,以表征患者和对照组之间微生物群的差异。结果:主要发现包括患者的Simpson指数显著升高(SMD = 0.42;95% CI, 0.25 ~ 0.60)。β多样性仅在SZ和MDD有显著差异。观察到微生物丰度的条件特异性变化:ASD中Rothia富集,SZ中产生h2s的属过多,MDD中Solobacterium和Leptotrichia减少。结论:总的来说,荟萃分析综合表明精神障碍患者口腔微生物群多样性的改变。疾病相关的微生物变化强调口腔微生物组是一个候选因素,需要进一步研究潜在的诊断应用和微生物靶向治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.

Introduction: Emerging research underscores the gut-brain axis in mental disorder pathophysiology, yet the oral microbiome's contribution to mental health remains underexplored. Elucidating oral microbial signatures in mental and neurological disorders may reveal novel pathobiological mechanisms and advance biomarker discovery for precision diagnostics and microbiota-targeted interventions.

Methods: This systematic review and meta-analysis investigates oral microbiota alterations across 6 different mental disorders, by synthesizing data from 20 case-control studies retrieved from PubMed, Embase, and Cochrane Library. Relative microbial abundance and beta diversity indices were extracted from between-group comparisons. Random-effects meta-analyses were conducted for alpha diversity to characterize microbiota differences between patients and controls.

Results: Key findings included a significantly higher Simpson Index in patients (SMD = 0.42; 95% CI, 0.25 to 0.60) compared to controls. Beta diversity varied significantly only in SZ and MDD. Condition-specific variations in microbial abundance were observed: Rothia enrichment in ASD, overrepresentation of H2S-producing genera in SZ, and reduced Solobacterium and Leptotrichia in MDD.

Conclusion: Collectively, the meta-analytical synthesis suggests alterations in oral microbiota diversity across mental disorders. Disease-associated microbial shifts highlight the oral microbiome as a candidate factor warranting further investigation for potential diagnostic applications and microbial-targeted therapeutic strategies.

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来源期刊
CiteScore
8.00
自引率
4.40%
发文量
52
审稿时长
12 weeks
期刊介绍: As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies. Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics. Article types: original articles, notes, review articles, mini-reviews and commentaries
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