免疫球蛋白g4相关的硬化性乳腺炎：MRI表现和文献复习。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunologic Research Pub Date : 2025-08-05 DOI:10.1007/s12026-025-09668-9

Lishan Wang, Fan Yang, Xiaoyan Hu, Na Li, Jie Gou, Wei Lin, Shengjian Zhang

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引用次数: 0

摘要

免疫球蛋白g4相关疾病（IgG4-RD）是一种罕见的免疫介导的纤维炎症性疾病，几乎可以影响任何器官，其中乳房受累（igg4相关硬化性乳腺炎，IgG4-RM）尤为罕见。这种疾病主要影响中老年妇女，由于非特异性临床和影像学特征，经常被误诊为恶性肿瘤。我们报告一例44岁女性右侧乳房无痛肿块，超声低回声表现和磁共振成像（MRI）特征，包括高ADC值和均匀增强，持续时间-强度曲线（TIC）。组织病理学证实为IgG4-RM， 12个月后无复发。回顾了24篇已发表的讲座，强调了IgG4-RM的诊断挑战和成像变异性。

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Immunoglobulin G4-related sclerosing mastitis: MRI findings and the literature review.

Immunoglobulin G4-related disease (IgG4-RD) is a rare immune-mediated fibro-inflammatory condition that can affect nearly any organ, with breast involvement (IgG4-related sclerosing mastitis, IgG4-RM) being exceptionally uncommon. This disease primarily affects middle-aged to elderly women and is frequently misdiagnosed as malignancy due to non-specific clinical and imaging features. We report a case of a 44-year-old woman with a painless right breast mass showing hypoechoic ultrasound findings and magnetic resonance imaging (MRI) characteristics, including a high ADC value and homogeneous enhancement with a persistent time-intensity curve (TIC). Histopathology confirmed IgG4-RM, with no recurrence after 12 months. A review of 24 published lectures highlights the diagnostic challenges and imaging variability of IgG4-RM.

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来源期刊

Immunologic Research 医学-免疫学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.