全α-选择性唾液酰化合成唾液酰半乳糖类似物。

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-04 DOI:10.1093/bbb/zbaf117

Asuka Ogawa, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Hiromune Ando

引用次数: 0

摘要

描述了唾液基半乳糖（NeuGal）类似物的流线型合成。利用双环唾液酰供体对合适的Gal受体进行完全α-选择性唾液酰化，合成Neuα(2,6)Gal和Neuα(2,3)Gal单元。NeuGal通过C5氨基修饰和磺化得到具有氨基连接物的NeuGal类似物，用于生物学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of Sialylgalactose Analogs via Fully α-Selective Sialylation.

A streamlined synthesis of sialylgalactose (NeuGal) analogs is described. Neuα(2,6)Gal and Neuα(2,3)Gal units were synthesized via fully α-selective sialylation of suitable Gal acceptors using a bicyclic sialyl donor. NeuGals were diversified through C5 amino group modification and sulfation, yielding NeuGal analogs with an amino linker for biological studies.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).