药物化学：药物、辅助药物和辅助药物

IF 0.6 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemie in Unserer Zeit Pub Date : 2025-07-14 DOI:10.1002/ciuz.202400044

Matthias Ducci

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引用次数: 0

摘要

将具有药理活性的化合物输送到机体所需的作用部位的一个重要策略是前药概念。这类药物含有，例如，实际活性成分的前体或被添加的部分结构掩盖的化合物。在生物体中，前药被代谢成药物。下面用几个例子来解释这个原理。此外，本文还就如何在高中化学课中实施这一主题提出了建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemie im pharmazeutischen Kontext: Drugs, Pro- und Codrugs

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Chemie im pharmazeutischen Kontext: Drugs, Pro- und Codrugs

An important strategy for delivering pharmacologically active compounds to the desired site of action in the organism is the prodrug concept. Such drugs contain, for example, a precursor of the actual active ingredient or a compound masked by an added partial structure. In the organism, the prodrug is metabolized into a drug. This principle is explained using several examples. In addition, a suggestion is made as to how this topic can be implemented in chemistry lessons at upper secondary level.

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来源期刊

Chemie in Unserer Zeit 化学-化学综合

CiteScore

0.70

自引率

75.00%

发文量

审稿时长

>12 weeks

期刊介绍： Chemie in unserer Zeit informiert zuverlässig über aktuelle Entwicklungen aus der Chemie und ihren Nachbardisziplinen. Der Leser erhält spannende Einblicke in alle Bereiche dieser zukunftsträchtigen Wissenschaft, dabei werden auch komplexe Sachverhalte verständlich aufbereitet. Namhafte Experten bringen Neuentwicklungen von großer Tragweite näher - farbig illustriert und leserfreundlich präsentiert. Von wissenschaftlichen Übersichten, studienbegleitenden Materialien, nachvollziehbaren Experimenten bis hin zu brisanten Themen aus Umweltchemie und aktueller gesellschaftlicher Diskussion. Übersichtsartikel und abwechslungsreiche Rubriken vermitteln Fachwissen auf unterhaltsame Art und geben eine Hilfe bei der Orientierung im Fachgebiet.