{"title":"在胆管镜引导下肝外胆管癌的穿刺活检中，在同一部位进行多次活检是否能提高标本的充分性？","authors":"Takahisa Ogawa, Yoshihide Kanno, Shinsuke Koshita, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Kento Hosokawa, Hidehito Sumiya, Yutaka Noda, Kei Ito","doi":"10.1002/jgh3.70246","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Cholangioscopy-guided mapping biopsy (CMB) is performed for preoperative evaluation of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness of CMB using a SpyBite Max and to determine the effectiveness of multiple biopsy strokes from the same site.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Between August 2020 and October 2022, 21 patients with extrahepatic cholangiocarcinoma were enrolled in this prospective observational study. The primary outcome was the rate of site-based successful biopsies, which was defined as the acquisition of epithelium-containing material appropriate for diagnosing benignity/malignancy from each site. The cumulative success rate of obtaining appropriate materials increased by increasing biopsy strokes from 1 to 4.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The cholangioscope could be advanced to all 80 target sites. The overall adequate specimen rate was 67% (142/212). The overall rate of site-based successful biopsies was 83% (66/80). The cumulative success rate of obtaining appropriate materials did not significantly improve by increasing the number of biopsy strokes from 1 (81%) to 4 (86%).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The biopsy material was obtained for 83% of the required sites. However, repetitive biopsy strokes for the same site did not improve the rate of site-based successful biopsy. This study was registered in UMIN (UMIN000041530).</p>\n </section>\n </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70246","citationCount":"0","resultStr":"{\"title\":\"Dose Performing Multiple Biopsy Strokes From the Same Site Improve Specimen Adequacy in Cholangioscopy-Guided Mapping Biopsy for Extrahepatic Cholangiocarcinoma?\",\"authors\":\"Takahisa Ogawa, Yoshihide Kanno, Shinsuke Koshita, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Kento Hosokawa, Hidehito Sumiya, Yutaka Noda, Kei Ito\",\"doi\":\"10.1002/jgh3.70246\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Cholangioscopy-guided mapping biopsy (CMB) is performed for preoperative evaluation of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness of CMB using a SpyBite Max and to determine the effectiveness of multiple biopsy strokes from the same site.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Between August 2020 and October 2022, 21 patients with extrahepatic cholangiocarcinoma were enrolled in this prospective observational study. The primary outcome was the rate of site-based successful biopsies, which was defined as the acquisition of epithelium-containing material appropriate for diagnosing benignity/malignancy from each site. The cumulative success rate of obtaining appropriate materials increased by increasing biopsy strokes from 1 to 4.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The cholangioscope could be advanced to all 80 target sites. The overall adequate specimen rate was 67% (142/212). The overall rate of site-based successful biopsies was 83% (66/80). The cumulative success rate of obtaining appropriate materials did not significantly improve by increasing the number of biopsy strokes from 1 (81%) to 4 (86%).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The biopsy material was obtained for 83% of the required sites. However, repetitive biopsy strokes for the same site did not improve the rate of site-based successful biopsy. This study was registered in UMIN (UMIN000041530).</p>\\n </section>\\n </div>\",\"PeriodicalId\":45861,\"journal\":{\"name\":\"JGH Open\",\"volume\":\"9 8\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70246\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JGH Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70246\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JGH Open","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Dose Performing Multiple Biopsy Strokes From the Same Site Improve Specimen Adequacy in Cholangioscopy-Guided Mapping Biopsy for Extrahepatic Cholangiocarcinoma?
Objectives
Cholangioscopy-guided mapping biopsy (CMB) is performed for preoperative evaluation of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness of CMB using a SpyBite Max and to determine the effectiveness of multiple biopsy strokes from the same site.
Methods
Between August 2020 and October 2022, 21 patients with extrahepatic cholangiocarcinoma were enrolled in this prospective observational study. The primary outcome was the rate of site-based successful biopsies, which was defined as the acquisition of epithelium-containing material appropriate for diagnosing benignity/malignancy from each site. The cumulative success rate of obtaining appropriate materials increased by increasing biopsy strokes from 1 to 4.
Results
The cholangioscope could be advanced to all 80 target sites. The overall adequate specimen rate was 67% (142/212). The overall rate of site-based successful biopsies was 83% (66/80). The cumulative success rate of obtaining appropriate materials did not significantly improve by increasing the number of biopsy strokes from 1 (81%) to 4 (86%).
Conclusions
The biopsy material was obtained for 83% of the required sites. However, repetitive biopsy strokes for the same site did not improve the rate of site-based successful biopsy. This study was registered in UMIN (UMIN000041530).
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