Kevin E. Agner, Luke G. Comisford, Alec G. Kotler, Jacob A. Wells, Michael C. Larkins
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Demographic and treatment variables were analyzed using Cox regression, and a log-rank analysis was used to assess 5-year overall survival (5y OS).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 1391 patients diagnosed with localized SPBS were identified. Multivariate analysis revealed that increasing age at diagnosis (HR = 2.25, <i>p</i> < 0.001) and higher income (HR = 1.471; <i>p</i> < 0.001) were significantly associated with decreased 5y OS, while being married was associated with improved survival (HR = 0.671, <i>p</i> < 0.001). Furthermore, treatment with radiation therapy (HR = 0.613, <i>p</i> < 0.001) and gross total resection (HR = 0.657; <i>p</i> = 0.020) were associated with improved survival outcomes. Univariate analysis confirmed the demographic factor significance, with radiotherapy combined with surgery being associated with improved survival versus sole radiotherapy (49.4% vs. 40.8%; <i>p</i> = 0.004).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This population-based analysis of SPBS highlights key prognostic factors for 5y OS. Increased age, higher income, and single marital status were associated with worse outcomes, while radiation therapy and greater extent of surgical procedure improved survival. Notably, radiotherapy combined with surgery showed better survival than radiation alone, challenging current national guidelines that recommend radiotherapy with or without surgery. Additionally, gross total resection demonstrated the highest overall survival among the various surgical procedures. These findings suggest that incorporating combined therapy into treatment protocols could improve outcomes and refine future guidelines.</p>\n </section>\n </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70299","citationCount":"0","resultStr":"{\"title\":\"Population-Based Survival Analysis of Solitary Plasmacytoma of Spine in the United States From 2000 to 2020\",\"authors\":\"Kevin E. Agner, Luke G. Comisford, Alec G. Kotler, Jacob A. Wells, Michael C. Larkins\",\"doi\":\"10.1002/cnr2.70299\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Solitary plasmacytomas of bone of the spine (SPBS) are rare tumors associated with significant morbidity and mortality, especially with progression to multiple myeloma.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>While demographic and treatment factors influencing survival have been investigated in previous studies, analysis using the most recent population data and assessing more granular data such as the extent of surgical resection in conjunction with radiotherapy has yet to be performed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The Surveillance, Epidemiology, and End Results (SEER) Program was queried for patients with a diagnosis of SPBS (ICD-0-3 code 9731/3). Demographic and treatment variables were analyzed using Cox regression, and a log-rank analysis was used to assess 5-year overall survival (5y OS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>A total of 1391 patients diagnosed with localized SPBS were identified. Multivariate analysis revealed that increasing age at diagnosis (HR = 2.25, <i>p</i> < 0.001) and higher income (HR = 1.471; <i>p</i> < 0.001) were significantly associated with decreased 5y OS, while being married was associated with improved survival (HR = 0.671, <i>p</i> < 0.001). Furthermore, treatment with radiation therapy (HR = 0.613, <i>p</i> < 0.001) and gross total resection (HR = 0.657; <i>p</i> = 0.020) were associated with improved survival outcomes. 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引用次数: 0
摘要
背景：脊柱骨孤立性浆细胞瘤（SPBS）是一种罕见的肿瘤，发病率和死亡率高，尤其是进展为多发性骨髓瘤时。虽然在以前的研究中已经调查了影响生存的人口统计学和治疗因素，但使用最新的人口数据和评估更细粒度的数据（如手术切除与放疗结合的程度）进行分析尚未进行。方法对诊断为SPBS （ICD-0-3代码9731/3）的患者进行监测、流行病学和最终结果（SEER）程序查询。采用Cox回归分析人口学和治疗变量，采用log-rank分析评估5年总生存期（5y OS）。结果共发现1391例局限性SPBS患者。多因素分析显示，年龄越大（HR = 2.25, p < 0.001）、收入越高(HR = 1.471；p < 0.001)与5y生存率降低显著相关，而结婚与生存率提高相关（HR = 0.671, p < 0.001）。此外，放射治疗（HR = 0.613, p < 0.001）和总切除(HR = 0.657；P = 0.020)与改善的生存结果相关。单因素分析证实了人口统计学因素的显著性，与单纯放疗相比，放疗联合手术与生存率的提高相关(49.4% vs 40.8%；p = 0.004)。结论基于人群的SPBS分析强调了5年OS的关键预后因素。年龄的增加、收入的增加和单身婚姻状况与较差的预后相关，而放射治疗和较大程度的外科手术可提高生存率。值得注意的是，放疗联合手术比单独放疗显示出更好的生存率，这挑战了目前推荐放疗合并或不合并手术的国家指南。此外，在各种外科手术中，大体全切除术显示出最高的总生存率。这些发现表明，将联合治疗纳入治疗方案可以改善结果并完善未来的指导方针。
Population-Based Survival Analysis of Solitary Plasmacytoma of Spine in the United States From 2000 to 2020
Background
Solitary plasmacytomas of bone of the spine (SPBS) are rare tumors associated with significant morbidity and mortality, especially with progression to multiple myeloma.
Aims
While demographic and treatment factors influencing survival have been investigated in previous studies, analysis using the most recent population data and assessing more granular data such as the extent of surgical resection in conjunction with radiotherapy has yet to be performed.
Methods
The Surveillance, Epidemiology, and End Results (SEER) Program was queried for patients with a diagnosis of SPBS (ICD-0-3 code 9731/3). Demographic and treatment variables were analyzed using Cox regression, and a log-rank analysis was used to assess 5-year overall survival (5y OS).
Results
A total of 1391 patients diagnosed with localized SPBS were identified. Multivariate analysis revealed that increasing age at diagnosis (HR = 2.25, p < 0.001) and higher income (HR = 1.471; p < 0.001) were significantly associated with decreased 5y OS, while being married was associated with improved survival (HR = 0.671, p < 0.001). Furthermore, treatment with radiation therapy (HR = 0.613, p < 0.001) and gross total resection (HR = 0.657; p = 0.020) were associated with improved survival outcomes. Univariate analysis confirmed the demographic factor significance, with radiotherapy combined with surgery being associated with improved survival versus sole radiotherapy (49.4% vs. 40.8%; p = 0.004).
Conclusion
This population-based analysis of SPBS highlights key prognostic factors for 5y OS. Increased age, higher income, and single marital status were associated with worse outcomes, while radiation therapy and greater extent of surgical procedure improved survival. Notably, radiotherapy combined with surgery showed better survival than radiation alone, challenging current national guidelines that recommend radiotherapy with or without surgery. Additionally, gross total resection demonstrated the highest overall survival among the various surgical procedures. These findings suggest that incorporating combined therapy into treatment protocols could improve outcomes and refine future guidelines.
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