转录偶联修复：跨代保护基因组

IF 3.6 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-08-05 DOI:10.1016/j.gde.2025.102385

Bibhusita Pani , Evgeny Nudler

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引用次数: 0

摘要

生命的首要目标是确保遗传物质代代相传，尽管dna破坏因素不断构成威胁。为了应对这些挑战，生命进化出了复杂的机制来检测、发送信号和修复DNA损伤，从而防止可能导致发育异常或疾病的突变。在细胞快速增殖和分化的发育时期，DNA修复尤为重要。体细胞DNA损伤修复失败会导致组织功能障碍，而在胚胎发育过程中，这通常是致命的。转录机制在DNA修复机制中起着关键作用。这篇综述强调了目前对转录驱动或促进的DNA修复途径的见解，以及它们对保持基因组稳定性的重要贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcription-coupled repair: protecting genome across generations

The primary objective of life is to ensure the faithful transmission of genetic material across generations, despite the constant threat posed by DNA-damaging factors. To counter these challenges, life has evolved intricate mechanisms to detect, signal, and repair DNA damage, thereby preventing mutations that can cause developmental abnormalities or diseases. DNA repair is especially vital during development — a period of rapid cell proliferation and differentiation. Failure to repair DNA damage in somatic cells can result in tissue dysfunction, while during embryonic development, it is often fatal. Transcription machinery plays a key role in the mechanisms of DNA repair. This review highlights current insights into DNA repair pathways that are driven or facilitated by transcription and their essential contribution to preserving genome stability.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)