慢性肾脏疾病中继发性血小板反应受损是先前血小板激活的结果

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-08-05 DOI:10.1016/j.jacbts.2025.101355

Constance C.F.M.J. Baaten PhD , Julia Wollenhaupt PhD , Tobias M. Henning MD , Sonja Vondenhoff MS , Jonas R. Schröer MD , Eleni Stamellou MD, PhD, MS , Turgay Saritas MD, PhD , Berkan Kurt MD , Leonard Boger MD , Alessandra Antwerpen , Juliane Hermann PhD , Magdolna Nagy PhD , Marieke Sternkopf PhD , Eva Miriam Buhl PhD , Ute Raffetseder PhD , Paola E.J. van der Meijden PhD , Marijke J.E. Kuijpers PhD , Henri M.H. Spronk PhD , Stefan J. Schunk MD , Joachim Jankowski PhD , Heidi Noels PhD

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引用次数: 0

摘要

慢性肾脏疾病（CKD）患者发生血栓和出血性并发症的风险增加。关于CKD血小板缺陷的研究结果是相互矛盾的。因此，我们检测了未接受抗栓治疗的CKD 3 - 5期透析患者、服用乙酰水杨酸（ASA）的CKD5D/血液透析患者以及CKD小鼠模型的血小板功能。未接受抗栓治疗的晚期CKD患者表现为血小板预活化和部分继发性血小板功能障碍，主要是在胶原/GPVI刺激下。与未服用ASA的患者相比，服用ASA的血液透析患者的血小板显示出较轻的CKD相关继发性血小板功能障碍，在服用ASA与对照药的CKD小鼠中也有类似的观察结果。

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Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation

Patients with chronic kidney disease (CKD) are at increased risk of thrombotic and hemorrhagic complications. Findings on platelet defects in CKD are conflicting. Therefore, we examined platelet function in CKD stage 3 to 5 dialysis patients without antithrombotic therapy, in CKD5D/hemodialysis patients on acetylsalicylic acid (ASA) as well as in a CKD mouse model. Patients with advanced CKD without antithrombotic therapy show platelet preactivation with a partial secondary platelet dysfunction mainly upon collagen/GPVI stimulation. Platelets from hemodialysis patients on ASA showed a less severe CKD-associated secondary platelet dysfunction compared with those not taking ASA, with comparable observations in CKD mice on ASA vs vehicle.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.