Veronica Salais Michaus , Javier Cervantes-Bojalil , José O. Navarro-Fernández , Edith A. Fernandez-Figueroa , Roberto Herrera-Goepfert , Maria Fernanda Tejada-Pineda , Erika Ruiz-Garcia
{"title":"复发性肝外乳头状胆管癌伴CCNE1扩增、TP53突变及累及中枢神经系统1例卡培他滨异常反应病例报告","authors":"Veronica Salais Michaus , Javier Cervantes-Bojalil , José O. Navarro-Fernández , Edith A. Fernandez-Figueroa , Roberto Herrera-Goepfert , Maria Fernanda Tejada-Pineda , Erika Ruiz-Garcia","doi":"10.1016/j.hmedic.2025.100316","DOIUrl":null,"url":null,"abstract":"<div><div>Cholangiocarcinoma (CCA) is a heterogeneous disease; the incidence of brain metastases from CCA ranges from 0.15 % to 1.4 %. We present the case of a 50-year-old woman with recurrent extrahepatic cholangiocarcinoma involving the central nervous system (CNS) and improvement in overall survival (OS). Next-Generation Sequencing (NGS) was performed, revealing <em>CCNE1</em> amplification and a <em>TP53</em> mutation.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100316"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recurrent extrahepatic papillary cholangiocarcinoma with CCNE1 amplification, TP53 mutation and CNS involvement a capecitabine exceptional response case report\",\"authors\":\"Veronica Salais Michaus , Javier Cervantes-Bojalil , José O. Navarro-Fernández , Edith A. Fernandez-Figueroa , Roberto Herrera-Goepfert , Maria Fernanda Tejada-Pineda , Erika Ruiz-Garcia\",\"doi\":\"10.1016/j.hmedic.2025.100316\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cholangiocarcinoma (CCA) is a heterogeneous disease; the incidence of brain metastases from CCA ranges from 0.15 % to 1.4 %. We present the case of a 50-year-old woman with recurrent extrahepatic cholangiocarcinoma involving the central nervous system (CNS) and improvement in overall survival (OS). Next-Generation Sequencing (NGS) was performed, revealing <em>CCNE1</em> amplification and a <em>TP53</em> mutation.</div></div>\",\"PeriodicalId\":100908,\"journal\":{\"name\":\"Medical Reports\",\"volume\":\"14 \",\"pages\":\"Article 100316\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949918625001615\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918625001615","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Recurrent extrahepatic papillary cholangiocarcinoma with CCNE1 amplification, TP53 mutation and CNS involvement a capecitabine exceptional response case report
Cholangiocarcinoma (CCA) is a heterogeneous disease; the incidence of brain metastases from CCA ranges from 0.15 % to 1.4 %. We present the case of a 50-year-old woman with recurrent extrahepatic cholangiocarcinoma involving the central nervous system (CNS) and improvement in overall survival (OS). Next-Generation Sequencing (NGS) was performed, revealing CCNE1 amplification and a TP53 mutation.
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