癫痫患儿睡眠障碍与健康相关生活质量：一项护理人员调查

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-08-05 DOI:10.1016/j.yebeh.2025.110613

Luc Wiesmüller , Didare Strauch , Jan Schönberger , Victoria San Antonio-Arce , Thomas Bast , Susanne Schubert-Bast , Steffen Syrbe , Julia Jacobs , Kerstin Alexandra Klotz

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引用次数: 0

摘要

睡眠障碍在癫痫患者中很常见。在成人中，有证据表明睡眠质量下降及其对健康相关生活质量（HRQoL）的负面影响。然而，关于大型儿科队列的数据仍然有限。本研究旨在探讨癫痫与主观睡眠质量的关系及其与癫痫患儿HRQoL的关系。材料与方法对15年的CWE进行了家长在线调查。收集个人资料和医疗信息，并使用标准化问卷评估家长报告的睡眠质量（儿童睡眠习惯问卷）和HRQoL （KINDL®-问卷）。结果共调查CWE 304例，男性52.3%，年龄1 ~ 15岁，中位年龄7岁。发作频率从每天（25%）到每年少于一次（24.7%）不等。服用抗癫痫药物（ASM）的占93.8%，其中30%服用≥3次ASM。合并症，如自闭症或多动症，报告179名儿童（58.9%）。平均睡眠障碍评分为54.8分（SD 9.4），其中290例（95.4%）得分在41分以上，提示睡眠障碍。与仅白天发作的CWE相比，白天和夜间发作的CWE睡眠质量更差（p = 0.027）。使用镇静药物，如氯巴唑，与睡眠质量受损（p = 0.025）和睡眠时间缩短（p = 0.005）有关。结论：与无癫痫的儿童相比，cwe的睡眠质量较差，特别是当夜间癫痫发作时，无论痉挛次数或是否存在合并症。在CWE中，睡眠受损与较低的HRQoL相关。

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Sleep disturbances and health-related quality of life in children with epilepsy: A caregiver survey

Introduction

Sleep disorders are common in patients with epilepsy. In adults, evidence suggests reduced sleep quality and its negative impact on health-related quality of life (HRQoL). However, data on large pediatric cohorts remain limited. This study investigates the relationship between epilepsy and subjective sleep quality as well as its association with HRQoL in a large cohort of children with epilepsy (CWE).

Material and Methods

A parental online survey was conducted for CWE up to 15 years. Biographical and medical information was collected and standardized questionnaires were administered to assess parent reported sleep quality (Children’s Sleep Habit Questionnaire), and HRQoL (KINDL®-questionnaire).

Results

A total of 304 CWE (52.3 % male) were surveyed, with a median age of 7 years (range 1–15). Seizure frequency varied from daily (25 %) to less than once per year (24.7 %). Antiseizure medication (ASM) was used in 93.8 %, with 30 % receiving ≥ 3 ASMs. Comorbidities, such as autism or ADHD, were reported in 179 children (58.9 %).

The mean sleep disturbance score was 54.8 (SD 9.4), with 290 children (95.4 %) scoring above 41, indicating impaired sleep. CWE with both, daytime and nocturnal seizures had worse sleep quality compared to those with daytime seizures only (p = 0.027). The use of sedative medications, like clobazam, was associated with impaired sleep quality (p = 0.025) and shorter sleep duration (p = 0.005).

Conclusion

CWE experience poorer sleep quality compared to children without epilepsy, especially when nocturnal seizures are present, regardless of the number of ASMs or presence of comorbidities. In CWE, impaired sleep correlates with lower HRQoL.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.