小胶质细胞中的胰岛素信号传导：阿尔茨海默病中控制神经炎症和淀粉样蛋白病理的代谢开关

IF 30.9 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-08-05 DOI:10.1016/j.cmet.2025.06.005

Eugenio Barone, D. Allan Butterfield

引用次数: 0

摘要

胰岛素抵抗是阿尔茨海默病（AD）的一个危险因素。Chen等人1表明，小胶质胰岛素信号传导对代谢稳态和免疫调节至关重要，而胰岛素抵抗会损害AD患者的Aβ清除并促进神经炎症。他们的发现通过细胞类型特异性视角重新定义了阿尔茨海默病的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer’s disease

Insulin resistance is a risk factor for Alzheimer’s disease (AD). Chen et al.¹ show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.