神经元为肿瘤提供养分

IF 20 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-08-04 DOI:10.1038/s41593-025-02048-4

Laura Zelenka

引用次数: 0

摘要

神经似乎促进了附近癌症的侵袭性，但这种影响背后的机制尚不清楚。Hoover及其同事在《自然》杂志上发表的一项研究表明，乳腺癌细胞的代谢依赖于神经元。在癌细胞存在的情况下，神经元进行代谢重编程。这导致线粒体质量增加，然后转移到邻近的癌细胞，如共培养和去神经支配模型所示。作者开发了MitoTRACER，这是一种基因报告器，可以跟踪癌细胞对线粒体的转移和摄取。利用这个工具，他们证明了神经元来源的线粒体促进了癌症代谢、干细胞和对转移应激的抵抗力，最终促进了转移。命运图谱显示，线粒体受体癌细胞或其后代在转移部位富集。这些发现确定了神经元线粒体是癌症的助推器，强调了神经元驱动的代谢是癌症进展的关键驱动因素，也是预防转移的潜在治疗靶点。原始参考文献：Nature https://doi.org/10.1038/s41586-025-09176-8 （2025）

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.