糖原牧羊人引导戊糖磷酸途径的隐藏踪迹

IF 30.9 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-08-05 DOI:10.1016/j.cmet.2025.07.002

Lin Wang, Kaili Ma, Lianjun Zhang, Ping-Chih Ho

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引用次数: 0

摘要

在最近的一项Molecular Cell研究中，1 Zhou等人阐明了糖原分解衍生的葡萄糖-1-磷酸如何通过葡萄糖-6-磷酸脱氢酶的变乙酰激活和液-液相分离介导的代谢区室介导葡萄糖-6-磷酸进入戊糖磷酸途径的来源特异性途径。这种区室化的分布使糖原溶解通量产生的烟酰胺腺嘌呤二核苷酸磷酸（NADPH）有效减少，通过维持氧化还原稳态来促进Tm细胞的持久性。

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Glycogen shepherd guides the hidden trail of pentose phosphate pathway

In a recent Molecular Cell study,¹ Zhou et al. elucidated how glycogenolysis-derived glucose-1-phosphate mediates source-specific routing of glucose-6-phosphate into the pentose phosphate pathway through allosteric activation of glucose-6-phosphate dehydrogenase and liquid-liquid phase separation-mediated metabolic compartments. This compartmentalized distribution enables efficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) generation from glycogenolytic flux, promoting Tm cell persistence by maintaining redox homeostasis.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.