用于液-液界面自动检测和监测的可移动光学传感器。

IF 3.7 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
SLAS Technology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI:10.1016/j.slast.2025.100335
Rodrigo Moreno, Jonas Jensen, Shahbaz Tareq Bandesha, Simone Peters, Andres Faina, Kasper Stoy
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引用次数: 0

摘要

液液萃取(LLE)是许多实验室实验中必不可少的操作。然而,大多数自动LLE设备专注于检测过程中某一时刻的液-液界面,通常是在分离时,而很少关注液体沉淀时的状态。在本文中,我们提出了一种具有移动光学传感器和光源的LLE装置,该装置沿着容器移动,而不是相对于传感器移动的混合物。利用可解释的自动检测算法分析光强模式,可以在容器的不同位置检测界面,误差小于2mm,并在沉降过程中进行监测。该装置在电池界面材料合成过程中使用清油和水的混合物以及两个提取步骤进行测试。结果表明,该装置能够检测沿容器不同位置的界面,即使直径发生变化。通过对沉降过程的监测,我们还发现检测到的信号变化最大的发生在液-液界面位置附近,我们也利用这一信息对其进行了印证。随着时间的推移,传感器在不同位置的测量记录可以用来检测液体的不同性质,这可以改善对过程的控制,也可以减轻重复过程成本高的化学领域的可重复性问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Movable optical sensor for automatic detection and monitoring of liquid-liquid interfaces.

Liquid-liquid extraction (LLE) is an essential operation in many laboratory experiments. However, most automatic LLE devices concentrate on detecting the liquid-liquid interface at one moment in the process, usually at separation, and pay little attention to the state of the liquids as they settle. In this paper, we present an LLE device with a moving optical sensor and light source that move along a vessel instead of the mixture moving relative to the sensor. Analyzing the patterns of light intensity with explainable automatic detection algorithms, the interface can be detected at different positions in the vessel with an error below 2 mm and monitored during the settling process. The device is tested using a mixture of clear oil and water and two extraction steps in a battery interface material synthesis process. Results show that the setup is able to detect interfaces at different positions along the vessel, even with changes in diameter. By monitoring the settling process, we also found that the biggest change in the signal detected occurs around the liquid-liquid interface position, and we also use this information to corroborate it. The recording of sensor measurements at different positions over time can be used to detect different properties of the liquids, which improves control over the process and could also alleviate reproducibility problems in areas of chemistry in which it is costly to repeat procedures.

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来源期刊
SLAS Technology
SLAS Technology Computer Science-Computer Science Applications
CiteScore
6.30
自引率
7.40%
发文量
47
审稿时长
106 days
期刊介绍: SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.
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