患有川崎病的男性患冠状动脉瘤的几率是女性的两倍多。

IF 2 4区 医学 Q2 PEDIATRICS
Paediatrics & child health Pub Date : 2025-04-03 eCollection Date: 2025-07-01 DOI:10.1093/pch/pxae106
Laurence Watelle, Andrea Dahoud, Samuel Blais, Rosie Scuccimarri, Claudia Renaud, Brian W McCrindle, Dereck Human, Frédéric Dallaire, Nagib Dahdah
{"title":"患有川崎病的男性患冠状动脉瘤的几率是女性的两倍多。","authors":"Laurence Watelle, Andrea Dahoud, Samuel Blais, Rosie Scuccimarri, Claudia Renaud, Brian W McCrindle, Dereck Human, Frédéric Dallaire, Nagib Dahdah","doi":"10.1093/pch/pxae106","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Kawasaki disease (KD) is the leading cause of acquired childhood coronary aneurysms (CAA). Males are more affected than females, with lower survival from cardiac events and normalization rates. This study aimed to determine the association between biological sex and CAA risk and evaluate the association with baseline biochemical inflammatory markers by biological sex.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study involved children ≤10 years old diagnosed with KD in five Canadian centres. Adjusted CAA risk differences between sexes were computed using binomial regression. Associations between inflammatory markers and CAA risk were analyzed using logistic regression with interaction terms between sex and inflammatory markers.</p><p><strong>Results: </strong>From 2004 to 2015, 1382 patients were diagnosed with KD and 812 (59%) were males. Median age, fever total duration, and fever duration at therapy initiation were similar between the sexes. The cumulative incidence of medium to large (Z ≥ 5) CAA was higher in males [70/812 (8.6%)] compared to females [19/570 (3.3%)], with an adjusted risk difference of 4.6 % (95% confidence interval [CI] 2.1 to 7.1). Large (Z > 10) aneurysms were more prevalent in males (adjusted risk difference of 3.3%, 95% CI 1.7 to 5.0). Most inflammatory markers were positively associated with CAA risk, but the association was not statistically different between sexes.</p><p><strong>Conclusion: </strong>Males with KD are at higher risk of developing CAA compared to females. The majority of patients were presumed to be prepubertal, suggesting that hormonal influences are unlikely to be a significant factor. Future KD research based on biological sex categorization should focus on patient risk stratification and long-term prognostic evaluation.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"250-256"},"PeriodicalIF":2.0000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316523/pdf/","citationCount":"0","resultStr":"{\"title\":\"Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.\",\"authors\":\"Laurence Watelle, Andrea Dahoud, Samuel Blais, Rosie Scuccimarri, Claudia Renaud, Brian W McCrindle, Dereck Human, Frédéric Dallaire, Nagib Dahdah\",\"doi\":\"10.1093/pch/pxae106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Kawasaki disease (KD) is the leading cause of acquired childhood coronary aneurysms (CAA). Males are more affected than females, with lower survival from cardiac events and normalization rates. This study aimed to determine the association between biological sex and CAA risk and evaluate the association with baseline biochemical inflammatory markers by biological sex.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study involved children ≤10 years old diagnosed with KD in five Canadian centres. Adjusted CAA risk differences between sexes were computed using binomial regression. Associations between inflammatory markers and CAA risk were analyzed using logistic regression with interaction terms between sex and inflammatory markers.</p><p><strong>Results: </strong>From 2004 to 2015, 1382 patients were diagnosed with KD and 812 (59%) were males. Median age, fever total duration, and fever duration at therapy initiation were similar between the sexes. The cumulative incidence of medium to large (Z ≥ 5) CAA was higher in males [70/812 (8.6%)] compared to females [19/570 (3.3%)], with an adjusted risk difference of 4.6 % (95% confidence interval [CI] 2.1 to 7.1). Large (Z > 10) aneurysms were more prevalent in males (adjusted risk difference of 3.3%, 95% CI 1.7 to 5.0). Most inflammatory markers were positively associated with CAA risk, but the association was not statistically different between sexes.</p><p><strong>Conclusion: </strong>Males with KD are at higher risk of developing CAA compared to females. The majority of patients were presumed to be prepubertal, suggesting that hormonal influences are unlikely to be a significant factor. Future KD research based on biological sex categorization should focus on patient risk stratification and long-term prognostic evaluation.</p>\",\"PeriodicalId\":19730,\"journal\":{\"name\":\"Paediatrics & child health\",\"volume\":\"30 4\",\"pages\":\"250-256\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316523/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Paediatrics & child health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/pch/pxae106\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Paediatrics & child health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/pch/pxae106","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

目的:川崎病(KD)是儿童获得性冠状动脉瘤(CAA)的主要病因。男性比女性更容易受到影响,心脏事件的存活率和正常化率较低。本研究旨在确定生物性别与CAA风险之间的关系,并评估生物性别与基线生化炎症标志物的关系。方法:这项多中心回顾性队列研究纳入了加拿大5个中心诊断为KD的≤10岁儿童。使用二项回归计算性别间调整后的CAA风险差异。使用逻辑回归分析炎症标志物与CAA风险之间的关系,并考虑性别和炎症标志物之间的相互作用。结果:2004 - 2015年确诊KD患者1382例,其中男性812例(59%)。治疗开始时的中位年龄、发烧总持续时间和发烧持续时间在两性之间相似。男性中大型(Z≥5)CAA的累积发病率[70/812(8.6%)]高于女性[19/570(3.3%)],调整后的风险差异为4.6%(95%置信区间[CI] 2.1 ~ 7.1)。大动脉瘤(zbbb10)在男性中更为普遍(调整后的风险差异为3.3%,95% CI为1.7 ~ 5.0)。大多数炎症标志物与CAA风险呈正相关,但性别间无统计学差异。结论:男性KD患者发生CAA的风险高于女性。大多数患者被认为是青春期前,这表明激素的影响不太可能是一个重要因素。未来基于生物学性别分类的KD研究应侧重于患者风险分层和长期预后评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.

Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.

Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.

Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.

Objectives: Kawasaki disease (KD) is the leading cause of acquired childhood coronary aneurysms (CAA). Males are more affected than females, with lower survival from cardiac events and normalization rates. This study aimed to determine the association between biological sex and CAA risk and evaluate the association with baseline biochemical inflammatory markers by biological sex.

Methods: This multicenter retrospective cohort study involved children ≤10 years old diagnosed with KD in five Canadian centres. Adjusted CAA risk differences between sexes were computed using binomial regression. Associations between inflammatory markers and CAA risk were analyzed using logistic regression with interaction terms between sex and inflammatory markers.

Results: From 2004 to 2015, 1382 patients were diagnosed with KD and 812 (59%) were males. Median age, fever total duration, and fever duration at therapy initiation were similar between the sexes. The cumulative incidence of medium to large (Z ≥ 5) CAA was higher in males [70/812 (8.6%)] compared to females [19/570 (3.3%)], with an adjusted risk difference of 4.6 % (95% confidence interval [CI] 2.1 to 7.1). Large (Z > 10) aneurysms were more prevalent in males (adjusted risk difference of 3.3%, 95% CI 1.7 to 5.0). Most inflammatory markers were positively associated with CAA risk, but the association was not statistically different between sexes.

Conclusion: Males with KD are at higher risk of developing CAA compared to females. The majority of patients were presumed to be prepubertal, suggesting that hormonal influences are unlikely to be a significant factor. Future KD research based on biological sex categorization should focus on patient risk stratification and long-term prognostic evaluation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Paediatrics & child health
Paediatrics & child health 医学-小儿科
CiteScore
2.10
自引率
5.30%
发文量
208
审稿时长
>12 weeks
期刊介绍: Paediatrics & Child Health (PCH) is the official journal of the Canadian Paediatric Society, and the only peer-reviewed paediatric journal in Canada. Its mission is to advocate for the health and well-being of all Canadian children and youth and to educate child and youth health professionals across the country. PCH reaches 8,000 paediatricians, family physicians and other child and youth health professionals, as well as ministers and officials in various levels of government who are involved with child and youth health policy in Canada.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信