恶性肿瘤ORMDL研究进展

IF 2.8 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
OncoTargets and therapy Pub Date : 2025-07-28 eCollection Date: 2025-01-01 DOI:10.2147/OTT.S537194
Hao Wang, Zhongquan Yi, Song Yan, Yihao Wang, Weisong Zhang, Rongqi Guo, Yangyang Li, Rui Wang, Heng Li, Xia Li, JianXiang Song
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引用次数: 0

摘要

ORMDL蛋白(ORMDL1, ORMDL2, ORMDL3)是内质网(ER)中的跨膜蛋白,可调节鞘脂代谢,维持内质网稳态,调节细胞应激反应。它们影响细胞增殖、凋亡和代谢平衡。最近的研究强调了ORMDL蛋白在多种肿瘤中的表达和功能改变,包括乳腺癌、DLBCL、结直肠癌和肺癌。ormdl负性调节丝氨酸棕榈酰转移酶(SPT),影响神经酰胺和鞘脂代谢,在肿瘤细胞增殖、侵袭性和耐药中起关键作用。ORMDL表达失调可能破坏鞘脂代谢,引发内质网应激,损害自噬。研究ORMDL在癌症中的功能可以为肿瘤的发生和发展提供新的见解。ORMDL表达可作为癌症诊断、预后和治疗反应预测的潜在生物标志物。靶向ORMDL或其代谢网络为癌症治疗提供了有希望的策略。尽管ormdl的研究仍处于早期阶段,但仍需进一步研究其在肿瘤微环境中的作用、与免疫系统的相互作用以及在个性化医疗中的应用。对ORMDL蛋白的深入了解将提高肿瘤的诊断、治疗和新治疗方法的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances in ORMDL Research in Malignant Tumors: A Review.

Advances in ORMDL Research in Malignant Tumors: A Review.

ORMDL proteins (ORMDL1, ORMDL2, ORMDL3) are transmembrane proteins in the endoplasmic reticulum (ER) that regulate sphingolipid metabolism, maintain ER homeostasis, and modulate cellular stress responses. They influence cell proliferation, apoptosis, and metabolic balance. Recent studies have highlighted the altered expression and function of ORMDL proteins in various tumors, including breast cancer, DLBCL, colorectal cancer, and lung cancer. ORMDLs negatively regulate serine palmitoyltransferase (SPT), affecting ceramide and sphingolipid metabolism, which plays a key role in tumor cell proliferation, invasiveness, and resistance to therapy. The dysregulation of ORMDL expression may disrupt sphingolipid metabolism, trigger ER stress, and impair autophagy. Investigating ORMDL functions in cancer could lead to novel insights into tumor development and progression. ORMDL expression may serve as a potential biomarker for cancer diagnosis, prognosis, and therapeutic response prediction. Targeting ORMDL or its metabolic networks offers promising strategies for cancer therapy. Although research on ORMDLs is still in its early stages, further studies are needed to explore their roles in the tumor microenvironment, interactions with the immune system, and applications in personalized medicine. A deeper understanding of ORMDL proteins will enhance tumor diagnosis, treatment, and the development of new therapeutic approaches.

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来源期刊
OncoTargets and therapy
OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY
CiteScore
9.70
自引率
0.00%
发文量
221
审稿时长
1 months
期刊介绍: OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.
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