塑料相关化学物质与阿尔茨海默病淀粉样蛋白β和认知状态的关联。

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-03 DOI:10.1177/13872877251364559

Rodrigo Canovas, James D Doecke, Christopher J Fowler, Jurgen Fripp, Xianyu Wang, Jochen F Mueller, Ayomi Jayarathne, Chang He, Ahmed Elagali, Sarah Dunlop, Colin L Masters

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引用次数: 0

摘要

阿尔茨海默病（AD）在痴呆发病前约20年以淀粉样蛋白-β (Aβ)为特征。邻苯二甲酸盐（通常添加到塑料中以增加柔韧性）和双酚单体已被证明会干扰神经活动/大脑功能。邻苯二甲酸盐和双酚暴露未显示个体尿液生物标志物与Aβ或临床表型（轻度认知障碍(MCI)/AD）的关联。评估四分位数的生物标志物，低邻苯二甲酸一（2-乙基己基）酯（MEHP），但没有其他邻苯二甲酸二（2-乙基己基）酯（DEHP）的生物标志物，与Aβ+和MCI/AD (q)相关

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Association of plastic-associated chemicals with Alzheimer's disease amyloid-β and cognitive status.

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) for ∼20 years prior to dementia onset. Phthalates, routinely added to plastics to increase flexibility, and bisphenol monomers, have been shown to interfere with neural activity/brain function. Phthalate and bisphenol exposure did not show association of individual urinary biomarkers with Aβ or clinical phenotype (mild cognitive impairment (MCI)/AD). Assessing biomarkers in quartiles, low mono(2-ethylhexyl) phthalate (MEHP), but not other biomarkers of di(2-ethylhexyl) phthalate (DEHP), was associated with Aβ+ and with having MCI/AD (q < 0.05), while high Bisphenol S (BPS) was associated with Aβ+ (q < 0.05). Mixture analysis shows significant association with MCI/AD but not Aβ.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.