m痘感染期的预测因子:使用越南国家m痘数据的精细和灰色亚分布危害模型的发现。

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Thi Ngoc Anh Hoang, Van Ngoc Hoang, Thi Thu Trang Dinh, Ngoc Long Vu, Ha Linh Quach
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引用次数: 0

摘要

调查麻疹传染期的危险因素对于预防这一新发疾病至关重要,但证据仍然很少。本研究旨在确定越南m痘病例中与m痘传染性持续时间相关的危险因素。主要结局是m痘传染性的持续时间,定义在症状出现和首次m痘病毒阴性检测结果之间。采用Fine和Gray回归模型来评估感染期与几个风险因素之间的关联,同时考虑m痘死亡的竞争风险。大多数麻疹病例在30天内康复。与艾滋病毒阴性或在单一机构接受治疗的患者相比,感染艾滋病毒或在多个机构接受治疗的mpox患者清除感染的发生率较低。在回归模型中,有皮疹或粘膜病变(亚分布风险比= 0.62,95%可信区间= 0.46-0.83)、溃疡(0.57,0.41-0.80)或发热(0.62,0.46-0.83)的m痘症状患者的感染期明显延长。我们的研究结果为管理m痘病例提供了见解,特别是在报告散发病例的环境中易受长时间感染的病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictors of mpox infectious periods: findings from a fine and gray sub-distribution hazard model using Vietnamese national mpox data.

Investigating risk factors for mpox's infectious period is vital for preventing this emerging disease, yet evidence remains scarce. This study aimed to identify risk factors associated with the duration of mpox infectiousness among mpox cases in Vietnam. The primary outcome was the duration of the mpox infectiousness, defined between symptom onset and the first negative test result for the mpox virus. Fine and Gray's regression models were employed to assess the associations between the infectious period and several risk factors while accounting for competing risks of death by mpox. Most mpox cases recovered within 30 days. Patients with HIV or treated at multiple facilities for mpox had lower incidence rates of cleared infection compared to those who were HIV-negative or treated at a single facility. In regression models, patients with mpox symptoms of rash or mucosal lesions (sub-distribution hazard ratios = 0.62, 95% confidence interval = 0.46-0.83), ulcers (0.57, 0.41-0.80), or fever (0.62, 0.46-0.83) had significantly prolonged infectious periods than those without such symptoms. Our findings provided insights for managing mpox cases, especially those vulnerable to prolonged infectious periods in settings with sporadic cases reported.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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