Dongchao Liu, Zheng Xue, Jingxian Qi, Liang Yin, Bing Duan, Bulang Gao, Jie Mi
{"title":"经皮冠状动脉介入治疗不稳定心绞痛患者的定量血流比率与支架内再狭窄的关系。","authors":"Dongchao Liu, Zheng Xue, Jingxian Qi, Liang Yin, Bing Duan, Bulang Gao, Jie Mi","doi":"10.1097/MCA.0000000000001494","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) with in-stent restenosis (ISR) in patients with unstable angina.</p><p><strong>Materials and methods: </strong>Patients treated with PCI and follow-up for ISR were divided into a poor QFR group (QFR < 0.91) and a good QFR group with (QFR ≥ 0.91). All clinical data were analyzed.</p><p><strong>Results: </strong>Among 143 patients enrolled, 57 (39.9%) patients were in the poor QFR group and 86 (60.1%) in the good QFR group. After stenting, the stenosis was decreased to 0 from ≥80% before PCI. At 10-month follow-up, the incidence of ISR in the good QFR group was 6.9%, significantly lower than 33.9% in the poor QFR group (P < 0.05). QFR < 0.91 was a significant (P = 0.002) risk factor for ISR, 4.25 times that of patients with QFR ≥ 0.91. After adjusting for age and sex, the risk of developing ISR in patients with poor QFR was 4.51 times that in patients with good QFR [95% confidence interval (CI): 1.76-11.54, P = 0.002], and QFR < 0.91 (adjusted risk ratio: 6.57, 95% CI: 2.45-17.60, P < 0.001) and diabetes (adjusted risk ratio: 7.23, 95% CI: 2.81-18.60, P < 0.001) were two independent risk factors for ISR.</p><p><strong>Conclusion: </strong>A positive linear relationship exists between QFR and ISR after adjusting for age and sex, and poor QFR < 0.91 after PCI is a significant independent risk factor for ISR among unstable angina patients undergoing PCI.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"36 6","pages":"482-487"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of quantitative flow ratio with in-stent restenosis in patients with unstable angina undergoing percutaneous coronary intervention.\",\"authors\":\"Dongchao Liu, Zheng Xue, Jingxian Qi, Liang Yin, Bing Duan, Bulang Gao, Jie Mi\",\"doi\":\"10.1097/MCA.0000000000001494\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the association of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) with in-stent restenosis (ISR) in patients with unstable angina.</p><p><strong>Materials and methods: </strong>Patients treated with PCI and follow-up for ISR were divided into a poor QFR group (QFR < 0.91) and a good QFR group with (QFR ≥ 0.91). All clinical data were analyzed.</p><p><strong>Results: </strong>Among 143 patients enrolled, 57 (39.9%) patients were in the poor QFR group and 86 (60.1%) in the good QFR group. After stenting, the stenosis was decreased to 0 from ≥80% before PCI. At 10-month follow-up, the incidence of ISR in the good QFR group was 6.9%, significantly lower than 33.9% in the poor QFR group (P < 0.05). QFR < 0.91 was a significant (P = 0.002) risk factor for ISR, 4.25 times that of patients with QFR ≥ 0.91. After adjusting for age and sex, the risk of developing ISR in patients with poor QFR was 4.51 times that in patients with good QFR [95% confidence interval (CI): 1.76-11.54, P = 0.002], and QFR < 0.91 (adjusted risk ratio: 6.57, 95% CI: 2.45-17.60, P < 0.001) and diabetes (adjusted risk ratio: 7.23, 95% CI: 2.81-18.60, P < 0.001) were two independent risk factors for ISR.</p><p><strong>Conclusion: </strong>A positive linear relationship exists between QFR and ISR after adjusting for age and sex, and poor QFR < 0.91 after PCI is a significant independent risk factor for ISR among unstable angina patients undergoing PCI.</p>\",\"PeriodicalId\":10702,\"journal\":{\"name\":\"Coronary artery disease\",\"volume\":\"36 6\",\"pages\":\"482-487\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coronary artery disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MCA.0000000000001494\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronary artery disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCA.0000000000001494","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Association of quantitative flow ratio with in-stent restenosis in patients with unstable angina undergoing percutaneous coronary intervention.
Objective: To investigate the association of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) with in-stent restenosis (ISR) in patients with unstable angina.
Materials and methods: Patients treated with PCI and follow-up for ISR were divided into a poor QFR group (QFR < 0.91) and a good QFR group with (QFR ≥ 0.91). All clinical data were analyzed.
Results: Among 143 patients enrolled, 57 (39.9%) patients were in the poor QFR group and 86 (60.1%) in the good QFR group. After stenting, the stenosis was decreased to 0 from ≥80% before PCI. At 10-month follow-up, the incidence of ISR in the good QFR group was 6.9%, significantly lower than 33.9% in the poor QFR group (P < 0.05). QFR < 0.91 was a significant (P = 0.002) risk factor for ISR, 4.25 times that of patients with QFR ≥ 0.91. After adjusting for age and sex, the risk of developing ISR in patients with poor QFR was 4.51 times that in patients with good QFR [95% confidence interval (CI): 1.76-11.54, P = 0.002], and QFR < 0.91 (adjusted risk ratio: 6.57, 95% CI: 2.45-17.60, P < 0.001) and diabetes (adjusted risk ratio: 7.23, 95% CI: 2.81-18.60, P < 0.001) were two independent risk factors for ISR.
Conclusion: A positive linear relationship exists between QFR and ISR after adjusting for age and sex, and poor QFR < 0.91 after PCI is a significant independent risk factor for ISR among unstable angina patients undergoing PCI.
期刊介绍：
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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