INHBA:与肿瘤疾病密切相关的蛋白质编码基因

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Jiayi Ma, Yining Pan, Cheng Chen, Dongshuo Wang, Xiaolan Li, Chengfu Yuan
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引用次数: 0

摘要

导读:目前,恶性肿瘤仍在发展中,呈上升趋势,其预防、治疗和预后也比较困难。INHBA基因,也被称为抑制素β,在这种情况下发挥着广泛的作用。几位研究者通过研究证实,INHBA基因的异常表达影响了几种恶性肿瘤(宫颈、结肠、乳腺、胃等)的发展和预后。本研究旨在探讨INHBA与恶性肿瘤发生、发展、治疗及预后的关系。方法:通过查阅相关文献,对INHBA在恶性肿瘤中的生物学功能和机制的最新研究进行综述和评价。结果:INHBA的异常表达可导致多种肿瘤,包括宫颈癌、食管癌、乳腺癌、结直肠癌、鳞状细胞癌、膀胱癌、鼻咽癌、胃癌和卵巢癌。讨论:INHBA作为一种蛋白质编码基因,可影响多种肿瘤的发生发展及肿瘤患者的预后,提示INHBA可作为肿瘤治疗的靶点。然而,靶向治疗的研究尚不成熟,存在一定的安全风险。结论:研究结果表明INHBA基因在肿瘤发生和预后中均有作用。因此,它可能在恶性肿瘤的治疗中作为生物标志物或治疗靶点具有潜在的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
INHBA: A Protein-coding Gene Closely Related to Tumour Diseases.

Introduction: At present, malignant tumors are still under development with an increasing trend, and their prevention, treatment, and prognosis are also difficult. The INHBA gene, also known as inhibin β, has a wide range of roles to play in this context. Through studies, several researchers have confirmed that an abnormal expression of the INHBA gene affects the development and prognosis of several malignant tumors (cervical, colorectal, breast, gastric, etc). This study aims to investigate the relationship between INHBA and the occurrence, development, treatment, and prognosis of malignant tumors.

Methods: This review, which involved scanning of pertinent literature, describes and evaluates recent research on the biological functions and mechanisms of INHBA in malignancies.

Results: An aberrant expression of INHBA can lead to a variety of tumors, including cervical, esophageal, breast, colorectal, squamous cell, bladder, nasopharyngeal, gastric, and ovarian cancers.

Discussion: INHBA, as a protein-coding gene, can affect the development of various tumors and the prognosis of tumor patients, suggesting that INHBA can be a target for tumor therapy. However, the research on targeted therapy is still immature and has certain safety risks.

Conclusion: Research findings indicate that the INHBA gene plays a role in both carcinogenesis and prognosis. As such, it may have the potential utility as a biomarker or therapeutic target in the treatment of malignant tumors.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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