{"title":"在健康受试者和功能性消化不良患者中应用电影MRI评价胃蠕动。","authors":"Shotaro Oki, Tsutomu Takeda, Mariko Hojo, Shunsuke Nakamura, Takuya Kanazawa, Momoko Yamamoto, Tomoyo Iwano, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Nobuyuki Suzuki, Atsushi Ikeda, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Tomoyoshi Shibuya, Shuko Nojiri, Daisuke Asaoka, Andrea Todisco, Shuji Sato, Ryohei Kuwatsuru, Akihito Nagahara","doi":"10.14309/ctg.0000000000000900","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Functional dyspepsia (FD) is subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), each with a different pathophysiological mechanisms driving the symptoms of these syndromes. Cine MRI aids observation in any continuous cross-section and measures gastrointestinal peristalsis without radiation exposure. In this study, we aimed to evaluate gastric peristalsis in FD using cine MRI.</p><p><strong>Methods: </strong>This study was a prospective interventional study. Patients diagnosed with FD according to ROME IV diagnostic criteria were included. Cine MRI was performed before and after the test meal. Gastric maximum short axis diameter, amplitude, contraction frequency, peristaltic wave height, peristaltic wave velocity, and gastric motility index were evaluated and compared between healthy control (HC) and patients with FD (PDS/EPS).</p><p><strong>Results: </strong>This study consisted of 18 HC and 31 patients with FD (including 22 with PDS and 9 with EPS). Preprandial comparison of the HC, PDS, and EPS groups showed no significant difference. Postprandial comparison of the 3 groups showed significant differences in maximum short axis diameter of fornix (HC: 51.5 ± 9.1/PDS: 47.1 ± 10.3/EPS: 59.0 ± 13.6 mm, P = 0.045), amplitude of fornix (HC: 7.3 ± 5.1/PDS: 12.1 ± 4.3/EPS: 11.3 ± 8.7 mm, P = 0.009), contraction frequency (HC: 2.9 ± 0.3/PDS: 2.7 ± 0.5/EPS: 2.6 ± 0.2 times/min, P = 0.007), peristaltic wave height (HC: 14.9 ± 4.0/PDS: 9.2 ± 2.5/EPS: 9.5 ± 3.2 mm, P < 0.001), and gastric motility index (HC: 24.5 ± 7.1/PDS: 16.8 ± 6.1/EPS: 15.9 ± 6.3 mm 2 /s, P = 0.002).</p><p><strong>Discussion: </strong>Cine MRI can be used to visually evaluate gastric peristalsis dysfunction and impaired gastric accommodation in FD.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":"e00900"},"PeriodicalIF":3.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456574/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Gastric Peristalsis Using Cine MRI in Healthy Subjects and Patients With Functional Dyspepsia.\",\"authors\":\"Shotaro Oki, Tsutomu Takeda, Mariko Hojo, Shunsuke Nakamura, Takuya Kanazawa, Momoko Yamamoto, Tomoyo Iwano, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Nobuyuki Suzuki, Atsushi Ikeda, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Tomoyoshi Shibuya, Shuko Nojiri, Daisuke Asaoka, Andrea Todisco, Shuji Sato, Ryohei Kuwatsuru, Akihito Nagahara\",\"doi\":\"10.14309/ctg.0000000000000900\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Functional dyspepsia (FD) is subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), each with a different pathophysiological mechanisms driving the symptoms of these syndromes. Cine MRI aids observation in any continuous cross-section and measures gastrointestinal peristalsis without radiation exposure. In this study, we aimed to evaluate gastric peristalsis in FD using cine MRI.</p><p><strong>Methods: </strong>This study was a prospective interventional study. Patients diagnosed with FD according to ROME IV diagnostic criteria were included. Cine MRI was performed before and after the test meal. Gastric maximum short axis diameter, amplitude, contraction frequency, peristaltic wave height, peristaltic wave velocity, and gastric motility index were evaluated and compared between healthy control (HC) and patients with FD (PDS/EPS).</p><p><strong>Results: </strong>This study consisted of 18 HC and 31 patients with FD (including 22 with PDS and 9 with EPS). Preprandial comparison of the HC, PDS, and EPS groups showed no significant difference. Postprandial comparison of the 3 groups showed significant differences in maximum short axis diameter of fornix (HC: 51.5 ± 9.1/PDS: 47.1 ± 10.3/EPS: 59.0 ± 13.6 mm, P = 0.045), amplitude of fornix (HC: 7.3 ± 5.1/PDS: 12.1 ± 4.3/EPS: 11.3 ± 8.7 mm, P = 0.009), contraction frequency (HC: 2.9 ± 0.3/PDS: 2.7 ± 0.5/EPS: 2.6 ± 0.2 times/min, P = 0.007), peristaltic wave height (HC: 14.9 ± 4.0/PDS: 9.2 ± 2.5/EPS: 9.5 ± 3.2 mm, P < 0.001), and gastric motility index (HC: 24.5 ± 7.1/PDS: 16.8 ± 6.1/EPS: 15.9 ± 6.3 mm 2 /s, P = 0.002).</p><p><strong>Discussion: </strong>Cine MRI can be used to visually evaluate gastric peristalsis dysfunction and impaired gastric accommodation in FD.</p>\",\"PeriodicalId\":10278,\"journal\":{\"name\":\"Clinical and Translational Gastroenterology\",\"volume\":\" \",\"pages\":\"e00900\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456574/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Gastroenterology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14309/ctg.0000000000000900\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14309/ctg.0000000000000900","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Evaluation of Gastric Peristalsis Using Cine MRI in Healthy Subjects and Patients With Functional Dyspepsia.
Introduction: Functional dyspepsia (FD) is subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), each with a different pathophysiological mechanisms driving the symptoms of these syndromes. Cine MRI aids observation in any continuous cross-section and measures gastrointestinal peristalsis without radiation exposure. In this study, we aimed to evaluate gastric peristalsis in FD using cine MRI.
Methods: This study was a prospective interventional study. Patients diagnosed with FD according to ROME IV diagnostic criteria were included. Cine MRI was performed before and after the test meal. Gastric maximum short axis diameter, amplitude, contraction frequency, peristaltic wave height, peristaltic wave velocity, and gastric motility index were evaluated and compared between healthy control (HC) and patients with FD (PDS/EPS).
Results: This study consisted of 18 HC and 31 patients with FD (including 22 with PDS and 9 with EPS). Preprandial comparison of the HC, PDS, and EPS groups showed no significant difference. Postprandial comparison of the 3 groups showed significant differences in maximum short axis diameter of fornix (HC: 51.5 ± 9.1/PDS: 47.1 ± 10.3/EPS: 59.0 ± 13.6 mm, P = 0.045), amplitude of fornix (HC: 7.3 ± 5.1/PDS: 12.1 ± 4.3/EPS: 11.3 ± 8.7 mm, P = 0.009), contraction frequency (HC: 2.9 ± 0.3/PDS: 2.7 ± 0.5/EPS: 2.6 ± 0.2 times/min, P = 0.007), peristaltic wave height (HC: 14.9 ± 4.0/PDS: 9.2 ± 2.5/EPS: 9.5 ± 3.2 mm, P < 0.001), and gastric motility index (HC: 24.5 ± 7.1/PDS: 16.8 ± 6.1/EPS: 15.9 ± 6.3 mm 2 /s, P = 0.002).
Discussion: Cine MRI can be used to visually evaluate gastric peristalsis dysfunction and impaired gastric accommodation in FD.
期刊介绍：
Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease.
Colon and small bowel
Endoscopy and novel diagnostics
Esophagus
Functional GI disorders
Immunology of the GI tract
Microbiology of the GI tract
Inflammatory bowel disease
Pancreas and biliary tract
Liver
Pathology
Pediatrics
Preventative medicine
Nutrition/obesity
Stomach.
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