与年轻大鼠相比,酒精在老年大鼠的共济失调中产生性别差异,但在非空间认知方面没有。

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE
Emily L Kerr, Averi Garscia, Jadyn Hartwig, Sam Stumo, Audrey Crippen, Pravesh Sharma, Douglas B Matthews
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引用次数: 0

摘要

本研究探讨急性酒精暴露在老年大鼠与成年大鼠和青少年大鼠的共济失调和非空间认知方面是否存在性别差异。材料和方法:使用老年、年轻成年和青春期的Sprague-Dawley大鼠来评估性别和年龄相关的差异。对于急性酒精暴露,动物在测试前通过腹腔注射1或2 g/kg酒精。为了研究急性酒精暴露对平衡、运动控制和非空间学习的影响,动物在空中翻正反射(ARR)和莫里斯水迷宫(MWM)测试中进行了行为测试。在给予1.0或2.0 g/kg酒精60分钟后测定血液酒精水平。结果:在ARR中发现了性别差异,因为老年女性对急性酒精暴露的影响明显低于老年男性。年龄也显著影响ARR的表现,老龄动物对急性酒精的反应比年轻动物差。然而,这些与性别和年龄相关的差异在非空间MWM测试或血液酒精浓度中未被发现。结论:这些结果表明,急性酒精暴露的性别和年龄依赖效应是特定任务的。总之,这些发现强调了研究急性酒精对老年人影响的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alcohol produces sex differences in ataxia but not nonspatial cognition in aged rats compared to younger rats.

Introduction: This study investigated if acute alcohol exposure produces sex differences in aged rats compared to adult and adolescent rats on ataxia and nonspatial cognition.

Materials and methods: Sex- and age-related differences were assessed by using aged, young adult, and adolescent Sprague-Dawley rats. For acute alcohol exposure, animals were administered either 1 or 2 g/kg alcohol via intraperitoneal injection before testing. To examine the effects of acute alcohol exposure on balance and motor control and nonspatial learning, animals underwent behavioral testing in the aerial righting reflex (ARR) and Morris water maze (MWM) tests. Blood alcohol levels were determined 60 min following administration of either 1.0 or 2.0 g/kg alcohol.

Results: Sex differences were found in the ARR, as aged females were significantly less sensitive to the effect of acute alcohol exposure compared to aged males. Age was also found to significantly affect ARR performance, where aged animals performed worse than younger animals in response to acute alcohol. However, these sex- and age-related differences were not found in the nonspatial MWM test or in blood alcohol concentrations.

Conclusions: These results indicate that the sex- and age-dependent effects of acute alcohol exposure are task specific. In conclusion, these findings highlight the importance of studying the effects of acute alcohol on the aged population.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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