{"title":"Clozapine-associated肺炎","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31346","DOIUrl":null,"url":null,"abstract":"<p>Despite clozapine's recognized efficacy for patients with treatment-resistant schizophrenia, most clinicians are aware that it can cause such serious adverse effects as agranulocytosis, seizures, myocarditis, obstipation, and orthostatic hypotension. Less well known are clinical reports and research suggesting an increased risk of pneumonia (Cepaityte et al., 2021). Other than dosage reduction, there has been little guidance on prevention of clozapine-associated pneumonia, or whether clozapine can be reinstated after its resolution.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 9","pages":"2-6"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clozapine-associated pneumonia\",\"authors\":\"Y. W. Francis Lam Pharm.D., FCCP\",\"doi\":\"10.1002/pu.31346\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Despite clozapine's recognized efficacy for patients with treatment-resistant schizophrenia, most clinicians are aware that it can cause such serious adverse effects as agranulocytosis, seizures, myocarditis, obstipation, and orthostatic hypotension. Less well known are clinical reports and research suggesting an increased risk of pneumonia (Cepaityte et al., 2021). Other than dosage reduction, there has been little guidance on prevention of clozapine-associated pneumonia, or whether clozapine can be reinstated after its resolution.</p>\",\"PeriodicalId\":22275,\"journal\":{\"name\":\"The Brown University Psychopharmacology Update\",\"volume\":\"36 9\",\"pages\":\"2-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Brown University Psychopharmacology Update\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/pu.31346\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31346","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
尽管氯氮平对难治性精神分裂症的疗效得到公认，但大多数临床医生都意识到它可能导致严重的不良反应，如粒细胞缺乏症、癫痫发作、心肌炎、顽固性便秘和体位性低血压。鲜为人知的是临床报告和研究表明肺炎风险增加（Cepaityte et al., 2021）。除了减少剂量外，关于氯氮平相关性肺炎的预防以及氯氮平消退后是否可以重新使用的指导很少。
Despite clozapine's recognized efficacy for patients with treatment-resistant schizophrenia, most clinicians are aware that it can cause such serious adverse effects as agranulocytosis, seizures, myocarditis, obstipation, and orthostatic hypotension. Less well known are clinical reports and research suggesting an increased risk of pneumonia (Cepaityte et al., 2021). Other than dosage reduction, there has been little guidance on prevention of clozapine-associated pneumonia, or whether clozapine can be reinstated after its resolution.
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