Julia Oliveira Fernandes, Cassiano Augusto Rolim Bernardino, Francisco Walison Lima Silva, Gustavo Zanon de Moraes Goes de Oliveira, Luiara Rosa Cavalcanti, Claudio Sabbatini Capella Lopes, Bernardo Ferreira Braz, Claudio Fernando Mahler, Ricardo Erthal Santelli, Braulio Soares Archanjo, Emerson Schwingel Ribeiro, Fernando Henrique Cincotto
{"title":"基于SiO2/Al2O3/Sb2O5混合氧化物的增强电化学传感平台测定维生素D3","authors":"Julia Oliveira Fernandes, Cassiano Augusto Rolim Bernardino, Francisco Walison Lima Silva, Gustavo Zanon de Moraes Goes de Oliveira, Luiara Rosa Cavalcanti, Claudio Sabbatini Capella Lopes, Bernardo Ferreira Braz, Claudio Fernando Mahler, Ricardo Erthal Santelli, Braulio Soares Archanjo, Emerson Schwingel Ribeiro, Fernando Henrique Cincotto","doi":"10.1002/elan.70030","DOIUrl":null,"url":null,"abstract":"<p>Vitamin D is essential for health, and its quantification in supplements is important for immune support and disease prevention. The aim of this study was to develop an electrochemical sensor based on a glassy carbon electrode modified with the ternary oxide SiO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub>/Sb<sub>2</sub>O<sub>5</sub> for the determination of vitamin D3 in dietary supplements. The material was characterized by scanning electron microscopy, specific surface area analysis, and pore volume and diameter measurements. The analyses revealed spherical irregular particles, a high surface area of 339 m<sup>2</sup> g<sup>−</sup><sup>1</sup>, a pore volume of 0.19 cm³ g<sup>−</sup><sup>1</sup>, and an average pore diameter of 1.14 nm. These features enhance analyte adsorption and increase the electroactive area of the sensor. The electrochemical study, performed using cyclic voltammetry and differential pulse voltammetry, showed a shift in the oxidation potential of vitamin D<sub>3</sub> from +0.7 V (bare GCE) to +0.5 V with the modified electrode, along with a 65% increase in peak current, indicating a significant electrocatalytic effect. The sensor exhibited high selectivity and excellent sensitivity, with a detection limit of 0.12 µmol L<sup>−</sup><sup>1</sup> and a linear range from 0.67 to 50.0 µmol L<sup>−</sup><sup>1</sup>. Additionally, no significant interference from other fat-soluble vitamins (A, E, and K) was observed. Therefore, the developed sensor proved to be effective for the trace-level determination of vitamin D3 in commercial supplement samples.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"37 8","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhanced Electrochemical Sensing Platform Based on Mixed Oxide SiO2/Al2O3/Sb2O5 for Determination of Vitamin D3\",\"authors\":\"Julia Oliveira Fernandes, Cassiano Augusto Rolim Bernardino, Francisco Walison Lima Silva, Gustavo Zanon de Moraes Goes de Oliveira, Luiara Rosa Cavalcanti, Claudio Sabbatini Capella Lopes, Bernardo Ferreira Braz, Claudio Fernando Mahler, Ricardo Erthal Santelli, Braulio Soares Archanjo, Emerson Schwingel Ribeiro, Fernando Henrique Cincotto\",\"doi\":\"10.1002/elan.70030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Vitamin D is essential for health, and its quantification in supplements is important for immune support and disease prevention. The aim of this study was to develop an electrochemical sensor based on a glassy carbon electrode modified with the ternary oxide SiO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub>/Sb<sub>2</sub>O<sub>5</sub> for the determination of vitamin D3 in dietary supplements. The material was characterized by scanning electron microscopy, specific surface area analysis, and pore volume and diameter measurements. The analyses revealed spherical irregular particles, a high surface area of 339 m<sup>2</sup> g<sup>−</sup><sup>1</sup>, a pore volume of 0.19 cm³ g<sup>−</sup><sup>1</sup>, and an average pore diameter of 1.14 nm. These features enhance analyte adsorption and increase the electroactive area of the sensor. The electrochemical study, performed using cyclic voltammetry and differential pulse voltammetry, showed a shift in the oxidation potential of vitamin D<sub>3</sub> from +0.7 V (bare GCE) to +0.5 V with the modified electrode, along with a 65% increase in peak current, indicating a significant electrocatalytic effect. The sensor exhibited high selectivity and excellent sensitivity, with a detection limit of 0.12 µmol L<sup>−</sup><sup>1</sup> and a linear range from 0.67 to 50.0 µmol L<sup>−</sup><sup>1</sup>. Additionally, no significant interference from other fat-soluble vitamins (A, E, and K) was observed. Therefore, the developed sensor proved to be effective for the trace-level determination of vitamin D3 in commercial supplement samples.</p>\",\"PeriodicalId\":162,\"journal\":{\"name\":\"Electroanalysis\",\"volume\":\"37 8\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Electroanalysis\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.70030\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electroanalysis","FirstCategoryId":"92","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.70030","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Enhanced Electrochemical Sensing Platform Based on Mixed Oxide SiO2/Al2O3/Sb2O5 for Determination of Vitamin D3
Vitamin D is essential for health, and its quantification in supplements is important for immune support and disease prevention. The aim of this study was to develop an electrochemical sensor based on a glassy carbon electrode modified with the ternary oxide SiO2/Al2O3/Sb2O5 for the determination of vitamin D3 in dietary supplements. The material was characterized by scanning electron microscopy, specific surface area analysis, and pore volume and diameter measurements. The analyses revealed spherical irregular particles, a high surface area of 339 m2 g−1, a pore volume of 0.19 cm³ g−1, and an average pore diameter of 1.14 nm. These features enhance analyte adsorption and increase the electroactive area of the sensor. The electrochemical study, performed using cyclic voltammetry and differential pulse voltammetry, showed a shift in the oxidation potential of vitamin D3 from +0.7 V (bare GCE) to +0.5 V with the modified electrode, along with a 65% increase in peak current, indicating a significant electrocatalytic effect. The sensor exhibited high selectivity and excellent sensitivity, with a detection limit of 0.12 µmol L−1 and a linear range from 0.67 to 50.0 µmol L−1. Additionally, no significant interference from other fat-soluble vitamins (A, E, and K) was observed. Therefore, the developed sensor proved to be effective for the trace-level determination of vitamin D3 in commercial supplement samples.
期刊介绍：
Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications.
Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.
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