Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła-Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino
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Front Cover: Novel 4,5-Dihydrothiazole-Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents (ChemMedChem 15/2025)
The cover image depicts the ligand–receptor complexes of the most attractive synthesized ligands, FG-7 and FG-18 derivatives, within the 5-HT1A and 5-HT2C receptor subtypes. They are shown inside a brain, highlighting the in vivo assay results: FG-7 showed anxiolytic effects along with pro-cognitive properties, while FG-18, characterized by strong affinity and selectivity for the 5-HT2C receptor, also demonstrated a marked anxiolytic profile. The results emerging from the performed assays suggest that both FG-7 and FG-18 are promising candidates for further development. More details can be found in the research article 10.1002/cmdc.202500288 by Ferdinando Fiorino and co-workers.
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Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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