盐生植物赤芍三萜皂苷具有抗sars - cov -2的特性

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-08-04 DOI:10.1039/D5RA03089G
Ahmed Othman, Omnia Kutkat, Samar S. Mabrouk and Yhiya Amen
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引用次数: 0

摘要

盐生植物被认为是促进健康的植物化学物质的丰富来源。本研究旨在阐明盐生植物赤霉素(Anabasis setifera Moq)的化学成分及其抗病毒潜力。它生长在埃及的沙漠地区。采用多种色谱方法纯化了6种三萜齐墩烷皂苷(1-6),并通过HRMS和NMR对其进行了鉴定,其中山皂苷B-D为首次报道。此外,三种已知的三萜皂苷(4 - 6)被鉴定为spinacoside C (4), betavulgaroside IV(5)和(3β)-3-(β-D-glucuronopyranosyloxy)olean-12-en-23,28-dioic acid(6)。分离得到的三萜皂苷对严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)具有抑制作用。我们的研究为皂苷1、2和4的抗病毒活性提供了有价值的见解,其IC50值在2.339 ~ 6.837 μg mL−1之间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Triterpene saponins from the halophyte Anabasis setifera exhibit anti-SARS-CoV-2 properties

Triterpene saponins from the halophyte Anabasis setifera exhibit anti-SARS-CoV-2 properties

Halophytes are well-known as a rich source of health-promoting phytochemicals. This study aimed to elucidate the chemical constituents and antiviral potential of the halophyte Anabasis setifera Moq., growing in the desert areas of Egypt. Six triterpenoid oleanane saponins (1–6) were purified using several chromatographic procedures and identified via HRMS and NMR spectroscopic analyses, with solysaponin B–D being reported for the first time. Additionally, three known triterpene saponins (4–6) were identified as spinacoside C (4), betavulgaroside IV (5), and (3β)-3-(β-D-glucuronopyranosyloxy)olean-12-en-23,28-dioic acid (6). The isolated triterpene saponins were able to inhibit the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). Our study provides valuable insights into the promising antiviral activity of saponins 1, 2 and 4 with IC50 values ranged between 2.339 and 6.837 μg mL−1.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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