丝胶-聚乙二醇水凝胶作为一种创新的孕酮赋形剂:配方开发、表征、分子对接和毒性评价

IF 2.5 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Dona Deb, Deepjyoti Kalita, Mojibur R. Khan and Kamatchi Sankaranarayanan
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引用次数: 0

摘要

丝胶蛋白(SS)是一种丝源性蛋白,具有生物相容性和无毒性等诸多优点,是生物医学和制药领域制备水凝胶的理想材料。黄体酮(PRO)是一种天然激素,对调节女性身体的关键生理功能至关重要,如为受孕和怀孕做准备,但由于其低水溶性而面临挑战。因此,需要有效的配方来提高其溶解度和生物利用度。本研究以生物医学领域广泛使用的合成聚合物聚乙二醇(PEG)为原料,采用简单的共混方法在室温下合成水凝胶。该制剂的主要目的是实现PRO的控释,从而提高其治疗效果和患者依从性。采用傅里叶变换红外光谱(FTIR)、x射线衍射(XRD)、核磁共振(NMR)、扫描电镜(SEM)和热重分析(TGA)等多种表征技术对水凝胶的结构、形态和热性能进行了评价。分析了水凝胶的溶胀行为和药物释放动力学,证实了其用于PRO的控制递送的适用性。分子对接研究显示了PRO与SS和PEG可能的结合位点。此外,毒性研究表明水凝胶具有显著的无毒行为。最重要的是,合成的水凝胶由于其简单的制备工艺,生物相容性和对疏水药物PRO的有效控释,在生物医学领域具有潜在的应用前景,使其成为受控药物递送系统的有希望的候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sericin–polyethylene glycol hydrogel as an innovative excipient for progesterone delivery: formulation development, characterization, molecular docking and toxicity evaluation

Sericin–polyethylene glycol hydrogel as an innovative excipient for progesterone delivery: formulation development, characterization, molecular docking and toxicity evaluation

Sericin (SS), a silk-derived protein, possesses numerous advantages such as biocompatibility and non-toxicity, making it a promising material for hydrogel fabrication in biomedical and pharmaceutical fields. Progesterone (PRO), a natural hormone essential for regulating key physiological functions such as preparing the female body for conception and pregnancy, faces challenges due to its low water solubility. Therefore, effective formulations are required to enhance its solubility and bioavailability. In this study, a hydrogel was synthesized through a simple blending method at room temperature using SS and polyethylene glycol (PEG), a widely used synthetic polymer in biomedical fields. The primary objective of this formulation was to achieve controlled release of PRO, thereby improving its therapeutic efficacy and patient compliance. Various characterization techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA), were employed to evaluate the hydrogel's structural, morphological, and thermal properties. The swelling behaviour and drug release kinetics of the hydrogel were analysed, confirming its suitability for controlled delivery of PRO. Molecular docking studies show possible binding sites of PRO with SS and PEG. Furthermore, toxicity studies demonstrated the hydrogel's significant non-toxic behaviour. Most importantly, the synthesized hydrogel offers potential applications in the biomedical field due to its simple fabrication process, biocompatibility, and effective controlled release of hydrophobic drug PRO, making it a promising candidate for controlled drug delivery systems.

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来源期刊
New Journal of Chemistry
New Journal of Chemistry 化学-化学综合
CiteScore
5.30
自引率
6.10%
发文量
1832
审稿时长
2 months
期刊介绍: A journal for new directions in chemistry
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