动态数字射线照相法分析横膈膜曲率

IF 2.9 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Open Pub Date : 2025-08-05 DOI:10.1016/j.ejro.2025.100676

Takuya Hino , Akinori Tsunomori , Noriaki Wada , Akinori Hata , Taiki Fukuda , Yusei Nakamura , Yoshitake Yamada , Tomoyuki Hida , Mizuki Nishino , Masako Ueyama , Atsuko Kurosaki , Takeshi Kubo , Shoji Kudoh , Kousei Ishigami , Hiroto Hatabu

{"title":"动态数字射线照相法分析横膈膜曲率","authors":"Takuya Hino , Akinori Tsunomori , Noriaki Wada , Akinori Hata , Taiki Fukuda , Yusei Nakamura , Yoshitake Yamada , Tomoyuki Hida , Mizuki Nishino , Masako Ueyama , Atsuko Kurosaki , Takeshi Kubo , Shoji Kudoh , Kousei Ishigami , Hiroto Hatabu","doi":"10.1016/j.ejro.2025.100676","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients.</div></div><div><h3>Methods</h3><div>This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. AUD in full inspiration minus AUD in full expiration (ΔAUD) was also calculated. The diaphragmatic surface was demarcated manually on DDR image to calculate AUD. Three-group comparison of AUD and ΔAUD among normal, mild COPD, and severe COPD subjects was tested with one-way analysis of variance, followed by multiple comparison with Tukey-Kramer method. The diagnostic accuracy of COPD by ΔAUD was assessed using receiver-operating-characteristics (ROC) curve.</div></div><div><h3>Results</h3><div>Sixty-eight participants (36 men, 29 COPD patients) were enrolled. AUD in full inspiration was larger in healthy volunteers than in COPD patients (right, p < 0.001; left, p = 0.02). ΔAUD were different in the three-group comparison (right, normal, 208.7 ± 184.6 mm<sup>2</sup>, mild COPD, −18.1 ± 117.5 mm<sup>2</sup>, severe COPD −97.5 ± 150.0 mm<sup>2</sup>, p < 0.001; left, normal, 254.9 ± 131.5 mm<sup>2</sup>, mild COPD, −12.5 ± 136.5 mm<sup>2</sup>, severe COPD, −100.7 ± 134.1 mm<sup>2</sup>, p < 0.001). ROC curve showed high diagnostic performance of COPD by unilateral ΔAUD (right, area-under curve 0.942; left, area-under-curve 0.965).</div></div><div><h3>Conclusion</h3><div>The value of ΔAUD was smaller according to the severity of COPD. ΔAUD can be helpful in distinguishing healthy subjects from COPD patients.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100676"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diaphragmatic curvature analysis using dynamic digital radiography\",\"authors\":\"Takuya Hino , Akinori Tsunomori , Noriaki Wada , Akinori Hata , Taiki Fukuda , Yusei Nakamura , Yoshitake Yamada , Tomoyuki Hida , Mizuki Nishino , Masako Ueyama , Atsuko Kurosaki , Takeshi Kubo , Shoji Kudoh , Kousei Ishigami , Hiroto Hatabu\",\"doi\":\"10.1016/j.ejro.2025.100676\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients.</div></div><div><h3>Methods</h3><div>This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. AUD in full inspiration minus AUD in full expiration (ΔAUD) was also calculated. The diaphragmatic surface was demarcated manually on DDR image to calculate AUD. Three-group comparison of AUD and ΔAUD among normal, mild COPD, and severe COPD subjects was tested with one-way analysis of variance, followed by multiple comparison with Tukey-Kramer method. The diagnostic accuracy of COPD by ΔAUD was assessed using receiver-operating-characteristics (ROC) curve.</div></div><div><h3>Results</h3><div>Sixty-eight participants (36 men, 29 COPD patients) were enrolled. AUD in full inspiration was larger in healthy volunteers than in COPD patients (right, p < 0.001; left, p = 0.02). ΔAUD were different in the three-group comparison (right, normal, 208.7 ± 184.6 mm<sup>2</sup>, mild COPD, −18.1 ± 117.5 mm<sup>2</sup>, severe COPD −97.5 ± 150.0 mm<sup>2</sup>, p < 0.001; left, normal, 254.9 ± 131.5 mm<sup>2</sup>, mild COPD, −12.5 ± 136.5 mm<sup>2</sup>, severe COPD, −100.7 ± 134.1 mm<sup>2</sup>, p < 0.001). ROC curve showed high diagnostic performance of COPD by unilateral ΔAUD (right, area-under curve 0.942; left, area-under-curve 0.965).</div></div><div><h3>Conclusion</h3><div>The value of ΔAUD was smaller according to the severity of COPD. ΔAUD can be helpful in distinguishing healthy subjects from COPD patients.</div></div>\",\"PeriodicalId\":38076,\"journal\":{\"name\":\"European Journal of Radiology Open\",\"volume\":\"15 \",\"pages\":\"Article 100676\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Radiology Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352047725000437\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Radiology Open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352047725000437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

摘要

目的探讨动态数字x线摄影（DDR）获得的膈下面积（AUD）在鉴别慢性阻塞性肺疾病（COPD）患者中的价值。方法回顾性研究纳入2009 - 2014年在福大学医院招募的健康志愿者和COPD患者，接受DDR和肺功能检查。AUD定义为DDR图像上半膈下、同侧肋膈角与半膈顶部连线以上的区域。同时计算充分吸气时的澳元减去完全呼气时的澳元（ΔAUD）。在DDR图像上手动标定膈面，计算AUD。三组比较正常、轻度和重度COPD受试者的AUD和ΔAUD，采用单因素方差分析，然后采用Tukey-Kramer法进行多重比较。采用受试者-工作特征（ROC）曲线评价ΔAUD对COPD的诊断准确性。结果共纳入68名参与者（36名男性，29名COPD患者）。健康志愿者完全吸气时的AUD大于COPD患者(右，p <； 0.001；离开时,p = 0.02)。Δ澳大利亚是不同的三组比较(正常, 208.7±184.6  平方毫米,轻微的慢性阻塞性肺病, −18.1±117.5  平方毫米,严重的慢性阻塞性肺病 −97.5±150.0  平方毫米,p & lt; 0.001;离开,正常,254.9 ±131.5  平方毫米,轻微的慢性阻塞性肺病, −12.5±136.5  平方毫米,严重的慢性阻塞性肺病, −100.7±134.1  平方毫米,p & lt; 0.001)。ROC曲线显示单侧ΔAUD对COPD有较高的诊断价值(右，曲线下面积0.942；左侧，曲线下面积0.965)。结论ΔAUD值随COPD的严重程度而变小。ΔAUD可以帮助区分健康受试者和COPD患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Diaphragmatic curvature analysis using dynamic digital radiography

Purpose

To investigate area under diaphragm (AUD) obtained by dynamic digital radiography (DDR) for the differentiation between normal subjects and chronic obstructive pulmonary disease (COPD) patients.

Methods

This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. AUD in full inspiration minus AUD in full expiration (ΔAUD) was also calculated. The diaphragmatic surface was demarcated manually on DDR image to calculate AUD. Three-group comparison of AUD and ΔAUD among normal, mild COPD, and severe COPD subjects was tested with one-way analysis of variance, followed by multiple comparison with Tukey-Kramer method. The diagnostic accuracy of COPD by ΔAUD was assessed using receiver-operating-characteristics (ROC) curve.

Results

Sixty-eight participants (36 men, 29 COPD patients) were enrolled. AUD in full inspiration was larger in healthy volunteers than in COPD patients (right, p < 0.001; left, p = 0.02). ΔAUD were different in the three-group comparison (right, normal, 208.7 ± 184.6 mm², mild COPD, −18.1 ± 117.5 mm², severe COPD −97.5 ± 150.0 mm², p < 0.001; left, normal, 254.9 ± 131.5 mm², mild COPD, −12.5 ± 136.5 mm², severe COPD, −100.7 ± 134.1 mm², p < 0.001). ROC curve showed high diagnostic performance of COPD by unilateral ΔAUD (right, area-under curve 0.942; left, area-under-curve 0.965).