新辅助化疗后达到病理完全缓解的三阴性乳腺癌患者中枢神经系统复发：回顾性队列分析

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2025-08-05 DOI:10.1016/j.breast.2025.104553

Gabriel Berlingieri Polho , Yumi Ricucci Shinkado , Leticia Kimie Murazawa , Vinicius Vitor Oliveira , Victor Rocha Pinheiro , Diana del Cisne Pineda Labanda , Romualdo Barroso-Sousa , Luciana Rodrigues Carvalho Barros , Laura Testa , Renata Colombo Bonadio

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引用次数: 0

摘要

三阴性乳腺癌（TNBC）与远处转移的风险增加有关。虽然新辅助化疗后的病理完全缓解（pCR）预测了有利的结果，但数据表明，它可能不能完全预防中枢神经系统（CNS）复发。本研究分析了774例TNBC患者，以评估复发模式。虽然pCR患者的中枢神经系统复发率在数字上较低（5.0%对8.8%,p = 0.11），但在该组中，CNS复发率明显较高（50.0%对20.2%,p = 0.003）。这些结果表明，虽然pCR降低了总体复发风险，但存在以cns为主的明显失败模式。

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Central nervous system relapse in triple-negative breast cancer patients achieving pathological complete response after neoadjuvant chemotherapy: A retrospective cohort analysis

Triple-negative breast cancer (TNBC) is associated with an increased risk of distant metastases. While pathological complete response (pCR) after neoadjuvant chemotherapy predicts favorable outcomes, data suggest it may not uniformly protect against central nervous system (CNS) relapse.

This study analyzed 774 TNBC patients to assess recurrence patterns. While CNS recurrences were numerically lower in pCR patients (5.0 % vs 8.8 %, p = 0.11), they represented a significantly higher proportion of all relapses in this group (50.0 % vs 20.2 %, p = 0.003). These results suggest that while pCR reduces overall recurrence risk, there is a distinct pattern of CNS-predominant failure.

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.