化学而非机械刺激可降低TRPA1通道的横向流动性

IF 4 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2025-07-31 DOI:10.1016/j.ceca.2025.103059

Alicia Sampieri , Alexander Asanov , Aaron Pavel Rodríguez-Hernández , Ileana Tobías-Juárez , Daniel Martínez-Flores , Luis Vaca

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引用次数: 0

摘要

瞬时受体电位锚蛋白1 （TRPA1）是离子通道TRP超家族的成员。TRPA1通道是钙渗透性非选择性阳离子通道，在动物界高度保守。哺乳动物只有一个成员（TRPA1），而斑马鱼有两个成员（TRPA1a和TRPA1b）。TRPA1通道可被多种刺激激活，包括毒冷、机械刺激、钙、pH、活性氧和羰基物质。在本研究中，我们描述了异硫氰酸烯丙酯（AITC）和机械刺激对TRPA1b通道横向迁移的调节。我们发现只有AITC刺激改变了质膜上的通道扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical but not mechanical stimulation reduce TRPA1 channel lateral mobility

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Chemical but not mechanical stimulation reduce TRPA1 channel lateral mobility

The transient Receptor Potential Ankyrin 1 (TRPA1) is a member from the TRP superfamily of ion channels. TRPA1 channels are calcium-permeable nonselective cation channels, which are highly conserved throughout the animal kingdom. Mammals have only one member (TRPA1), while zebrafish has two (TRPA1a and TRPA1b). TRPA1 channels are activated by a plethora of stimuli, including noxious cold, mechanical stimulation, calcium, pH, reactive oxygen, and carbonyl species. In the present study we characterize the modulation of TRPA1b channel lateral mobility by Allyl isothiocyanate (AITC) and mechanical stimulation. We show that only AITC stimulation alters channel diffusion at the plasma membrane.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes