LncRNA SNHG15 facilitates the advancement of preeclampsia via the miR-451a/ATF2 axis.

Preeclampsia (PE) is a pregnancy complication that poses a major risk to both the maternal and the fetal's safety. By studying the role and mechanism of LncRNA SNHG15 in preeclampsia pathogenesis, this study aimed to better understand the pathophysiology and prevention of PE. Placental samples and hypoxic trophoblast cell line--HTR8/SVneo were analyzed using qPCR to determine the differential expression of LncRNA SNHG15. Nuclear-cytoplasmic fractionation assays confirmed that LncRNA SNHG15 is predominantly localized in the cytoplasm of HTR8/SVneo cells, where it modulates cellular functions including proliferation, migration, and invasion. Using a dual luciferase reporter assay and rescue experiment, functions of miRNA-451a and LncRNA SNHG15 in HTR8/SVneo cells were examined. ATF2 expression levels in the hypoxic cell model and after LncRNA SNHG15 and miR-451a interference were confirmed by qPCR and Western blot. Evidence from this study indicates that LncRNA SNHG15 may be involved in the onset of preeclampsia, suggesting its viability as a novel treatment target.