{"title":"儿童应激源典型变异经历与海马结构和功能连通性的关系","authors":"Morgan Botdorf, Zehua Cui, Tracy Riggins","doi":"10.1002/jdn.70037","DOIUrl":null,"url":null,"abstract":"<p>Abuse and maltreatment have been associated with negative effects on the developing brain through the hypothalamic–pituitary–adrenal (HPA) axis, the body's central stress response system. Theoretically, similar pathophysiology occurs when children experience more moderate forms of stress (i.e., changing schools); however, evidence for this association is lacking. Therefore, the current study explored the effects of typical variations in stressful life events on the development of the hippocampus, a brain region susceptible to stress. Data from a 3-year accelerated longitudinal sample of 4- and 6-year-old children were used to assess the links between stressful events and the development of hippocampal subfield volumes (<i>N</i><sub>total</sub> = 90) and functional connectivity (<i>N</i><sub>total</sub> = 83). In the 4-year-old cohort, stressful experiences were related to an overall slower growth in CA1 and subiculum volume from age 5 to 6. In the 6-year-old cohort, stressful experiences were related to smaller CA2–4/DG volume at age 6 and an overall faster decrease in subiculum volume from age 6 to 7. Small effects were observed regarding the relations between stress and hippocampal functional connectivity; however, they did not survive multiple comparisons. Results from analyses comparing cohorts showed that the relations between stressful events and CA2–4/DG volume and change in subiculum volume significantly differed between the younger and older cohorts. Overall, these findings demonstrate the links between typical variations in stress and hippocampal development and highlight the region- and age-specific nature of the effects of stress. Together, this work emphasizes the importance of understanding how brain development may be influenced by stress in all forms, as stress-related alterations in hippocampal development have been linked to variations in cognitive processes (e.g., memory) and risk for psychopathology (e.g., major depressive disorder).</p>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 5","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jdn.70037","citationCount":"0","resultStr":"{\"title\":\"Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood\",\"authors\":\"Morgan Botdorf, Zehua Cui, Tracy Riggins\",\"doi\":\"10.1002/jdn.70037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Abuse and maltreatment have been associated with negative effects on the developing brain through the hypothalamic–pituitary–adrenal (HPA) axis, the body's central stress response system. Theoretically, similar pathophysiology occurs when children experience more moderate forms of stress (i.e., changing schools); however, evidence for this association is lacking. Therefore, the current study explored the effects of typical variations in stressful life events on the development of the hippocampus, a brain region susceptible to stress. Data from a 3-year accelerated longitudinal sample of 4- and 6-year-old children were used to assess the links between stressful events and the development of hippocampal subfield volumes (<i>N</i><sub>total</sub> = 90) and functional connectivity (<i>N</i><sub>total</sub> = 83). In the 4-year-old cohort, stressful experiences were related to an overall slower growth in CA1 and subiculum volume from age 5 to 6. In the 6-year-old cohort, stressful experiences were related to smaller CA2–4/DG volume at age 6 and an overall faster decrease in subiculum volume from age 6 to 7. Small effects were observed regarding the relations between stress and hippocampal functional connectivity; however, they did not survive multiple comparisons. Results from analyses comparing cohorts showed that the relations between stressful events and CA2–4/DG volume and change in subiculum volume significantly differed between the younger and older cohorts. Overall, these findings demonstrate the links between typical variations in stress and hippocampal development and highlight the region- and age-specific nature of the effects of stress. Together, this work emphasizes the importance of understanding how brain development may be influenced by stress in all forms, as stress-related alterations in hippocampal development have been linked to variations in cognitive processes (e.g., memory) and risk for psychopathology (e.g., major depressive disorder).</p>\",\"PeriodicalId\":13914,\"journal\":{\"name\":\"International Journal of Developmental Neuroscience\",\"volume\":\"85 5\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jdn.70037\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Developmental Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70037\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70037","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood
Abuse and maltreatment have been associated with negative effects on the developing brain through the hypothalamic–pituitary–adrenal (HPA) axis, the body's central stress response system. Theoretically, similar pathophysiology occurs when children experience more moderate forms of stress (i.e., changing schools); however, evidence for this association is lacking. Therefore, the current study explored the effects of typical variations in stressful life events on the development of the hippocampus, a brain region susceptible to stress. Data from a 3-year accelerated longitudinal sample of 4- and 6-year-old children were used to assess the links between stressful events and the development of hippocampal subfield volumes (Ntotal = 90) and functional connectivity (Ntotal = 83). In the 4-year-old cohort, stressful experiences were related to an overall slower growth in CA1 and subiculum volume from age 5 to 6. In the 6-year-old cohort, stressful experiences were related to smaller CA2–4/DG volume at age 6 and an overall faster decrease in subiculum volume from age 6 to 7. Small effects were observed regarding the relations between stress and hippocampal functional connectivity; however, they did not survive multiple comparisons. Results from analyses comparing cohorts showed that the relations between stressful events and CA2–4/DG volume and change in subiculum volume significantly differed between the younger and older cohorts. Overall, these findings demonstrate the links between typical variations in stress and hippocampal development and highlight the region- and age-specific nature of the effects of stress. Together, this work emphasizes the importance of understanding how brain development may be influenced by stress in all forms, as stress-related alterations in hippocampal development have been linked to variations in cognitive processes (e.g., memory) and risk for psychopathology (e.g., major depressive disorder).
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
