间苯基顺式肉桂酸作为强根向倾斜抑制剂

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-30 DOI:10.1016/j.tet.2025.134848

Mitsuru Shindo , Takeshi Nishimura , Kozue Kodama , Yuuki Furusawa , Jun Sun , Hiromi Sugiyama , Takayuki Iwata , Naoya Wasano , Arihiro Kano , Miyo Terao Morita , Yoshiharu Fujii

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引用次数: 0

摘要

在我们之前的研究中，我们发现化合物(2Z,4E)-5-苯基戊-2,4-二烯酸（BMA）是一种有效的向地性弯曲抑制剂，报道了它是一种在10 nM处对乳酸根有效的先导化合物。在此基础上，我们进一步探索了顺式肉桂酸的衍生物，并鉴定出mPCA，一种具有极强抑制活性的间苯基顺式肉桂酸。与BMA一样，mPCA在低浓度下能有效抑制生菜向地弯曲，但不影响生菜根伸长和下胚轴向地性。mPCA的化学结构比BMA更简单，更容易合成，在植物生理研究和未来农化应用方面具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

meta-Phenyl-cis-cinnamic acid as a strong root gravitropism inhibitor

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meta-Phenyl-cis-cinnamic acid as a strong root gravitropism inhibitor

In our previous studies, we identified the compound (2Z,4E)-5-phenylpenta-2,4-dienoic acid (BMA) as a potent gravitropic bending inhibitor, reporting it as a lead compound effective at 10 nM on Lactuca radicles. Based on this, we further explored derivatives of cis-cinnamic acid and identified mPCA, a meta-phenyl-cis-cinnamic acid that exhibits extremely potent inhibitory activity. mPCA, like BMA, effectively inhibited gravitropic bending at low concentrations without affecting root elongation or hypocotyl gravitropism in lettuce. mPCA has a simpler chemical structure than BMA and is easier to synthesize mPCA has great potential as a candidate for plant physiological studies and future agrochemical applications.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.