{"title":"从碎片到形态：尾脊索动物模型的全身再生。","authors":"Yuval Rinkevich, Baruch Rinkevich","doi":"10.1038/s41536-025-00423-0","DOIUrl":null,"url":null,"abstract":"<p><p>Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlighting examples of whole-body regeneration (WBR), a peak form of regeneration, where entire organisms regenerate from minute body fragments. Among the many examples of WBR, we focus on botryllid ascidians, an intriguing group of invertebrate chordates that display chordate tissue complexity while demonstrating WBR from small fragments of blood vessels. Centering on WBR in the model species Botrylloides leachi, we outline shared characteristics of WBR across botryllid ascidians including the presence of circulating multipotent stem cells, systemic induction processes, and ensuing competition among regeneration sites, culminating in the restoration of a complete organism. This regeneration mode is distinct from those in mammals and humans. Further research may offer valuable insights into mechanisms by which tissue fragments reinstate new organisms.</p>","PeriodicalId":54236,"journal":{"name":"npj Regenerative Medicine","volume":"10 1","pages":"36"},"PeriodicalIF":6.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316915/pdf/","citationCount":"0","resultStr":"{\"title\":\"From fragment to form: whole-body regeneration in a model urochordate.\",\"authors\":\"Yuval Rinkevich, Baruch Rinkevich\",\"doi\":\"10.1038/s41536-025-00423-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlighting examples of whole-body regeneration (WBR), a peak form of regeneration, where entire organisms regenerate from minute body fragments. Among the many examples of WBR, we focus on botryllid ascidians, an intriguing group of invertebrate chordates that display chordate tissue complexity while demonstrating WBR from small fragments of blood vessels. Centering on WBR in the model species Botrylloides leachi, we outline shared characteristics of WBR across botryllid ascidians including the presence of circulating multipotent stem cells, systemic induction processes, and ensuing competition among regeneration sites, culminating in the restoration of a complete organism. This regeneration mode is distinct from those in mammals and humans. Further research may offer valuable insights into mechanisms by which tissue fragments reinstate new organisms.</p>\",\"PeriodicalId\":54236,\"journal\":{\"name\":\"npj Regenerative Medicine\",\"volume\":\"10 1\",\"pages\":\"36\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316915/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Regenerative Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41536-025-00423-0\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Regenerative Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41536-025-00423-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
From fragment to form: whole-body regeneration in a model urochordate.
Tissue and organ regeneration are common among aquatic invertebrates, yet these taxa and their potential as model organisms remain underexplored. We present evidence of extensive regenerative capabilities in aquatic invertebrates, highlighting examples of whole-body regeneration (WBR), a peak form of regeneration, where entire organisms regenerate from minute body fragments. Among the many examples of WBR, we focus on botryllid ascidians, an intriguing group of invertebrate chordates that display chordate tissue complexity while demonstrating WBR from small fragments of blood vessels. Centering on WBR in the model species Botrylloides leachi, we outline shared characteristics of WBR across botryllid ascidians including the presence of circulating multipotent stem cells, systemic induction processes, and ensuing competition among regeneration sites, culminating in the restoration of a complete organism. This regeneration mode is distinct from those in mammals and humans. Further research may offer valuable insights into mechanisms by which tissue fragments reinstate new organisms.
期刊介绍：
Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.
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