子宫颈癌妇女的生育能力保存。

IF 1.4 3区 医学 Q3 OBSTETRICS & GYNECOLOGY
Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-08-01 DOI:10.1055/s-0045-1810055
Ines Sellami, Emine Saïs, Fatoumata Souare, Céleste Becquart, Hélène Thomas, Charlotte Sonigo, Michaël Grynberg
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引用次数: 0

摘要

宫颈癌(CC)是影响年轻育龄妇女的最常见的恶性肿瘤之一,使生育能力保存(FP)成为其管理的关键考虑因素。FP技术的可行性取决于癌症分期和肿瘤治疗。在早期CC中,保留生育能力的手术可以提供给希望在不影响肿瘤安全的情况下保留生育能力的年轻患者。对于非转移性局部晚期疾病和淋巴结状态阴性的患者,新辅助化疗后保留生育能力的手术是一种选择。然而,对于需要根治性子宫切除术或盆腔放疗的局部晚期患者,FP可以使用卵母细胞、胚胎或卵巢组织冷冻保存进行。对于这些患者,未来怀孕是可能的通过代孕。最近,子宫转位被提出作为一种保留子宫解剖结构的替代方法,以防止子宫放射性损伤和避免代孕。这篇综述提供了对年轻CC患者可用的FP选择的全面概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fertility Preservation in Women with Cervical Cancer.

Cervical cancer (CC) is one of the most common malignancies affecting young women of childbearing age, making fertility preservation (FP) a pivotal consideration in its management. The feasibility of FP techniques depends on the cancer stage and oncological treatments. In early-stage CC, fertility-sparing surgery can be offered for young patients wishing to preserve fertility without compromising oncological safety. Neoadjuvant chemotherapy followed by fertility-sparing surgery is an alternative for patients with nonmetastatic locally advanced disease and negative lymph node status. Nevertheless, for patients with locally advanced disease requiring radical hysterectomy or pelvic radiotherapy, FP can be performed using oocyte, embryo, or ovarian tissue cryopreservation. For these patients, future pregnancy is possible through surrogacy. Recently, uterine transposition has been proposed as an alternative to preserve uterine anatomy to prevent uterine radio-induced damage and avoid surrogacy. This review provides a comprehensive overview of the FP options available for young patients with CC.

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来源期刊
Seminars in reproductive medicine
Seminars in reproductive medicine 医学-妇产科学
CiteScore
5.80
自引率
0.00%
发文量
24
审稿时长
6-12 weeks
期刊介绍: Seminars in Reproductive Medicine is a bi-monthly topic driven review journal that provides in-depth coverage of important advances in the understanding of normal and disordered human reproductive function, as well as new diagnostic and interventional techniques. Seminars in Reproductive Medicine offers an informed perspective on issues like male and female infertility, reproductive physiology, pharmacological hormonal manipulation, and state-of-the-art assisted reproductive technologies.
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