上睑下垂是男性不育症的一个值得关注的原因吗?

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Bhagyalaxmi Sahoo , Diptimayee Guru , Anwesha Pradhan , Soumya Ranjan Jena , Lisa Goutami , Jasmine Nayak , Ashutosh Sahu , Luna Samanta
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引用次数: 0

摘要

铁下垂是最近发现的一种受调控的细胞死亡形式,在包括男性生殖功能障碍在内的各种疾病的病理生理学中起着关键作用。本文就铁下垂与男性生殖健康的相互作用作一综述,重点探讨其分子机制。由于遗传、环境和生活方式等因素的综合作用,包括氧化应激、活性氧(ROS)、表观遗传改变和翻译后修饰(PTMs),全球男性生殖健康一直在恶化。铁下垂的特点是铁超载和脂质过氧化,导致睾丸损伤和精子发生受损,从而导致男性不育。虽然铁在维持精子发生和睾酮产生中起着至关重要的作用,但它的过载会引起氧化应激、ROS积累和睾丸下垂,从而破坏正常的生殖功能。抗氧化防御系统的失败、暴露于外源性物质(如亚砷酸盐、镉、邻苯二甲酸盐、双酚A、PM2.5)和铁中毒相关基因(FRGs)的改变等因素进一步加剧了睾丸功能障碍。本文综述了脂质、铁和谷胱甘肽代谢途径在铁下垂诱导中的关键作用,环境外源物对睾丸健康的影响,以及铁下垂抑制剂治疗男性不育症的潜在疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is ferroptosis a cause for concern in male infertility?
Ferroptosis, a recently identified form of regulated cell death, has emerged as a key player in the pathophysiology of various disorders, including male reproductive dysfunction. This review explores the interplay of ferroptosis with male reproductive health, focusing on the molecular mechanisms involved. Global male reproductive health has been deteriorating due to a combination of genetic, environmental, and lifestyle factors, including oxidative stress, reactive oxygen species (ROS), epigenetic alterations, and posttranslational modifications (PTMs). Ferroptosis is characterized by iron overload and lipid peroxidation, leading to testicular damage and impaired spermatogenesis, thus contributing to male infertility. While iron plays an essential role in maintaining spermatogenesis and testosterone production, its overload induces oxidative stress, ROS accumulation, and testicular ferroptosis, which disrupts normal reproductive function. Factors such as failure of antioxidant defense systems, exposure to xenobiotics (e.g., arsenite, cadmium, phthalates, bisphenol A, PM2.5), and alterations in ferroptosis-related genes (FRGs) further exacerbate testicular dysfunction. This review examines the critical role of lipid, iron, and glutathione metabolic pathways in ferroptosis induction, the effects of environmental xenobiotics on testicular health, and the potential therapeutic benefits of ferroptosis inhibitors in treating male infertility.
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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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