评估微塑料对母胎健康的新威胁:胎盘屏障穿透和胎儿发育后果。

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Amy S. Mathew , Abhirami Harjith , C. Guruvayoorappan
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引用次数: 0

摘要

微塑料(MPs)现在是无处不在的环境污染物,对环境和生态系统构成重大风险,在过去十年中,人们对其对生殖系统的潜在威胁的担忧得到了广泛认可。MPs由于体积小,可以很容易地通过生物屏障,如胎盘和血脑屏障。MPs通过胎盘屏障的能力引起了极大的关注,因为它们可能会传给下一代,影响后代的健康。本文综述了胎盘生物学及其屏障功能,以及MPs在胎盘中的转运能力。它还强调了胎盘在细胞水平、体内动物模型和人体研究中对MPs暴露的反应。为了全面了解MPs对母胎界面的影响,本文还对MPs对胎儿生长发育的影响进行了广泛的综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing microplastics as a novel threat to maternal-fetal health: Placental barrier penetration and fetal developmental consequences
Microplastics (MPs) are now ubiquitous environmental contaminants that pose major risks to the environment and ecosystem, and in the last decade, concern about their potential threats to the reproductive system has gained widespread recognition. MPs can readily pass through biological barriers such as the placental and blood-brain barriers due to their small size. The ability of MPs to cross the placental barrier causes utmost concern as they could pass to the next generation and affect the health of the offspring. This review addresses the placental biology and its barrier function, as well as the ability of the MPs to translocate across the placenta. It also draws emphasis to responses of the placenta to the exposure of MPs at the cellular level, in vivo animal models, and human studies. To give a thorough grasp of the impacts of MPs at the maternal-fetal interface, investigations on the effects of MPs on fetal growth and development are also extensively reviewed.
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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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